Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts.
Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts.
复制标题
癫痫的光声和光学相干断层扫描，具有高时空和空间分辨率以及双重光学对比度。
DOI：
10.1016/j.jneumeth.2013.04.001
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发表时间：
2013-06-15
影响因子：
3
通讯作者：
Wang, Lihong V.
中科院分区：
文献类型：
--
作者：
Tsytsarev, Vassiliy;Rao, Bin;Maslov, Konstantin I.;Li, Li;Wang, Lihong V.
高空间和时间分辨率的癫痫定位对于癫痫神经元的基础研究和癫痫的临床治疗都具有重要意义。在这次交流中，我们首次在动物模型中展示了具有高空间和时间分辨率以及双光学对比度的体内癫痫映射。通过深度分辨光学相干断层扫描信号与光学散射对比度的变化，我们观察到癫痫神经元活动调制癫痫神经元及其周围组织的光学折射率。同时，通过神经血管耦合机制和光吸收对比，我们使用光声信号来记录癫痫神经元周围微血管的血流动力学变化。癫痫标测结果由癫痫发作期间同时记录的脑电图信号证实。我们新的癫痫映射工具，具有高的时间和空间分辨率和双光学对比度，可能会发现许多应用，如药物开发和癫痫手术。
Epilepsy mapping with high spatial and temporal resolution has great significance for both fundamental research on epileptic neurons and the clinical management of epilepsy. In this communication, we demonstrate for the first time in vivo epilepsy mapping with high spatial and temporal resolution and dual optical contrasts in an animal model. Through the variations of a depthresolved optical coherence tomography signal with optical scattering contrast, we observed that epileptic neuron activities modulated the optical refractive index of epileptic neurons and their surrounding tissue. Simultaneously, through neurovasculature coupling mechanisms and optical absorption contrast, we used photoacoustic signals to document the hemodynamic changes of the microvasculature surrounding the epileptic neurons. The epilepsy mapping results were confirmed by a simultaneously recorded electroencephalogram signal during epileptic seizure. Our new epilepsy mapping tool, with high temporal and spatial resolution and dual optical contrasts, may find many applications, such as drug development and epilepsy surgery.
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影响因子：
3
作者：
Chen, Yu;Aguirre, Aaron D.;Ruvinskaya, Lana;Devor, Anna;Boas, David A.;Fujimoto, James G.
通讯作者：
Fujimoto, James G.
影响因子：
3.5
作者：
Liao, Lun-De;Lin, Chin-Teng;Li, Meng-Lin
通讯作者：
Li, Meng-Lin
影响因子：
3.4
作者：
Eberle MM;Reynolds CL;Szu JI;Wang Y;Hansen AM;Hsu MS;Islam MS;Binder DK;Park BH
通讯作者：
Park BH
影响因子：
6.3
作者：
Liao, Lun-De;Lin, Chin-Teng;Chen, You-Yin
通讯作者：
Chen, You-Yin
影响因子：
5.7
作者：
Liao, Lun-De;Li, Meng-Lin;Chen, You-Yin
通讯作者：
Chen, You-Yin