Innovations in osteomyelitis research: A review of animal models.
Innovations in osteomyelitis research: A review of animal models.
复制标题
骨髓炎研究的创新：动物模型综述。
DOI：
10.1002/ame2.12149
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发表时间：
2021-03
影响因子：
3.7
通讯作者：
Priddy LB
中科院分区：
文献类型：
--
作者：
Roux KM;Cobb LH;Seitz MA;Priddy LB
骨组织感染或骨髓炎已成为现代医疗保健中日益关注的问题，这在很大程度上是由于细菌（特别是金黄色葡萄球菌）中抗生素耐药性的增加。目前的护理标准包括积极的，长期的抗生素治疗结合感染组织的手术清创。虽然这种治疗可能足以解决一部分病例，但已报告感染复发和相关风险，包括长期使用抗生素的毒性。因此，需要产生更安全、更有效的骨髓炎治疗选择。为了测试治疗方案，需要密切模拟临床状况并允许准确评估治疗剂的动物模型。建立一个复制人类骨髓炎特征的模型仍然是科学家面临的挑战，因为涉及许多变量，包括选择适当的物种和方法来建立感染。本文综述了骨髓炎动物模型的完善，以反映临床疾病和测试的前瞻性治疗。本综述的目的是探讨有关使用动物进行骨髓炎治疗研究的研究，并鼓励进一步开发这种动物模型，将动物实验的结果转化为人类医学。本文综述了骨髓炎动物模型的完善，以反映临床疾病和测试的前瞻性治疗。本综述的目的是探讨有关使用动物进行骨髓炎治疗研究的研究，并鼓励进一步开发这种动物模型，将动物实验的结果转化为人类医学。本综述中讨论的模型利用三种主要方法诱导感染：创伤后、植入物和血源性。
Infection of bone tissue, or osteomyelitis, has become a growing concern in modern healthcare due in no small part to a rise in antibiotic resistance among bacteria, notably Staphylococcus aureus. The current standard of care involves aggressive, prolonged antibiotic therapy combined with surgical debridement of infected tissues. While this treatment may be sufficient for resolving a portion of cases, recurrences of the infection and associated risks including toxicity with long‐term antibiotic usage have been reported. Therefore, there exists a need to produce safer, more efficacious options of treatment for osteomyelitis. In order to test treatment regimens, animal models that closely mimic the clinical condition and allow for accurate evaluation of therapeutics are necessary. Establishing a model that replicates features of osteomyelitis in humans continues to be a challenge to scientists, as there are many variables involved, including choosing an appropriate species and method to establish infection. This review addresses the refinement of animal models of osteomyelitis to reflect the clinical disease and test prospective therapeutics. The aim of this review is to explore studies regarding the use of animals for osteomyelitis therapeutics research and encourage further development of such animal models for the translation of results from the animal experiment to human medicine. This review addresses the refinement of animal models of osteomyelitis to reflect the clinical disease and test prospective therapeutics. The aim of this review is to explore studies regarding the use of animals for osteomyelitis therapeutics research and encourage further development of such animal models for the translation of results from the animal experiment to human medicine. The models discussed in this review utilize three main methods for induction of infection: post‐traumatic, implants, and hematogenous.
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DOI：
10.1302/0301-620x.85b6.13509
发表时间：
2003-08-01
影响因子：
--
作者：
Ellington, JK;Harris, M;Hudson, M
通讯作者：
Hudson, M
影响因子：
3
作者：
Darouiche, RO;Landon, GC;Klima, M
通讯作者：
Klima, M
影响因子：
4.9
作者：
Chou, Teri G. Rosenbaum;Petti, Cathy A.;Bloebaum, Roy D.
通讯作者：
Bloebaum, Roy D.
影响因子：
2.2
作者：
DEHRING, DJ;CROCKER, SH;CLOUTIER, CT
通讯作者：
CLOUTIER, CT
DOI：
10.2106/00004623-198365030-00013
发表时间：
1983-01-01
影响因子：
5.3
作者：
FITZGERALD, RH
通讯作者：
FITZGERALD, RH