Lewis rats have greater response impulsivity than Fischer rats.
Lewis rats have greater response impulsivity than Fischer rats.
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DOI：
10.1016/j.addbeh.2014.02.008
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发表时间：
2014-11
影响因子：
4.4
通讯作者：
Grunberg, Neil E.
中科院分区：
文献类型：
--
作者：
Hamilton, Kristen R.;Potenza, Marc N.;Grunberg, Neil E.
冲动是一种立即采取行动而不考虑未来后果的倾向，与一系列有问题的行为有关。反应冲动是一种行为评估的冲动，以行为去抑制为特征，也与健康危险行为有关。反应冲动不同于选择冲动，选择冲动的特征是对延迟的不容忍。Lewis大鼠比Fischer大鼠有更高水平的选择冲动。然而，还没有研究检验Lewis和Fischer大鼠是否具有不同水平的反应冲动。本研究检测了这两个品系大鼠的反应冲动性。受试者为16只雄性Lewis和Fischer大鼠。用五选一系列反应时任务(5-CSRTT)测量大鼠的反应冲动性。此外，在运动活动室中测量他们的运动活动。在5-CSRTT评估中，Lewis大鼠比Fischer大鼠有更多的过早反应[F(1，14)=5.34，p<；0.05]，表明反应冲动水平更高。不同品系组大鼠的运动活动没有差异[F(1，14)=3.05，p=.10]，这表明整体运动不能解释5-CSRTT反应冲动性的组间差异。从这项研究可以得出结论，Lewis大鼠比Fischer大鼠具有更高水平的反应冲动，因此提供了一个有效的大鼠个体冲动差异的模型。
Impulsivity, a tendency toward immediate action without consideration of future consequences, is associated with a wide array of problematic behaviors. Response impulsivity, a type of behaviorally-assessed impulsivity characterized by behavioral disinhibition, is also associated with health risk behaviors. Response impulsivity is distinct from choice impulsivity, which is characterized by intolerance for delay. Lewis rats have higher levels of choice impulsivity than Fischer rats. However, no studies have examined whether Lewis and Fischer rats have different levels of response impulsivity. The present research examined response impulsivity in the two rat strains. Subjects were 16 male Lewis and Fischer rats. Rats’ response impulsivity was measured using the Five Choice Serial Reaction Time Task (5-CSRTT). In addition, their locomotor activity was measured in locomotor activity chambers. Lewis rats had more premature responses than Fischer rats during the 5-CSRTT assessment [F(1, 14) = 5.34, p < 0.05], indicating higher levels of response impulsivity. Locomotor activity did not differ between rat strain groups [F(1, 14) = 3.05, p = .10], suggesting that overall movement did not account for group differences in response impulsivity on the 5-CSRTT. It can be concluded from this research that Lewis rats have higher levels of response impulsivity than Fischer rats, and therefore provide a valid rat model of individual differences in impulsivity.
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