Effect of X-ray dose protraction and a tumor promoter on transformation induction in vitro.
Effect of X-ray dose protraction and a tumor promoter on transformation induction in vitro.
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X 射线剂量延长和肿瘤促进剂对体外转化诱导的影响。
DOI：
10.1080/09553008814551521
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发表时间：
1988
影响因子：
2.6
通讯作者：
Harrison,GH
中科院分区：
文献类型：
--
作者：
Balcer-Kubiczek,EK;Harrison,GH
我们研究了短暂照射(1min或更短)或长时间照射5h以上的X射线对C3H/10T1/2细胞存活和诱发肿瘤转化的影响，重点是长时间照射后残留的潜在转化损伤。照射后用0.1µg/ml的TPA(12-O-十四酰-佛波酯或佛波酯)慢性处理，观察照射后累积剂量为0.25~4Gy时的这种潜在损伤及其表达。在0.1µg/mlTPA/ml存在下，长时间和短时间X射线照射的转化发生率与X射线剂量呈线性关系，在不存在TPA的情况下，最佳拟合函数为三次函数，而不是二次函数。剂量延长引起的效应修正因子在TPA或不加TPA的情况下相似，在低剂量(最高2GY)时平均为4.6。在此剂量范围内，TPA引起的平均相变增强约为4。我们的结果表明，剂量延长并不改变相变的剂量-效应曲线的形状，而且TPA引起的形状变化也与剂量延长无关。
We have investigated the effects of X-rays given in a brief exposure (1 min or less) or protracted over 5 h, on cell survival and the induction of neoplastic transformation in C3H/10T1/2 cells with an emphasis on latent transformation damage remaining after protracted irradiation. This latent damage and its expression were investigated at accumulated doses of 0·25 to 4 Gy by chronic treatment with TPA (12-O-tetradecanoyl-phorbol-13-acetate or phorbol myristate acetate) at 0·1 µg/ml beginning after irradiation. Transformation incidence from protracted as well as brief X-irradiations was linearly related to X-ray dose in the presence of 0·1 µg/ml TPA/ml. In the absence of TPA, the best fits were obtained with cubic rather than quadratic functions. The effect-modifying factors due to dose protraction were similar with or without TPA and averaged 4·6 at low doses (up to 2 Gy). Also within this dose range average transformation enhancement due to TPA was approximately 4. Our results indicate that dose protraction does not change the shape the dose-response curve for transformation, and that the shape change induced by TPA is also independent of dose protraction.
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DOI：
10.1093/jnci/1.1.45
发表时间：
1940
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Robert D. Sall;M. J. Shear;J. Leiter;A. Perrault
通讯作者：
A. Perrault
X 射线、快裂变中子和回旋加速器产生的中子对 C3H/10T1/2 细胞进行致癌转化。
DOI：
10.1080/09553008314551321
发表时间：
1983
期刊：
International journal of radiation biology and related studies in physics, chemistry, and medicine
影响因子：
--
作者：
E. Balcer;G. H. Harrison
通讯作者：
G. H. Harrison
X 射线诱导 C3H 小鼠胚胎来源细胞系的转化。
影响因子：
11.2
作者：
Margaret Terzaghi;J. Little
通讯作者：
J. Little
紫外线照射和佛波酯对 C3H/10T1/2 CL8 小鼠胚胎成纤维细胞的转化
影响因子：
64.8
作者：
S. Mondal;C. Heidelberger
通讯作者：
C. Heidelberger
C3H/10T1/2 细胞培养物中的两阶段化学肿瘤发生。
影响因子：
11.2
作者：
S. Mondal;D. Brankow;C. Heidelberger
通讯作者：
C. Heidelberger