Acoustic-resolution photoacoustic microscope based on compact and low-cost delta configuration actuator.
Acoustic-resolution photoacoustic microscope based on compact and low-cost delta configuration actuator.
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DOI：
10.1016/j.ultras.2021.106549
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发表时间：
2022-01
期刊：
影响因子：
4.2
通讯作者：
Zhang HK
中科院分区：
文献类型：
--
作者：
Gao S;Tsumura R;Vang DP;Bisland K;Xu K;Tsunoi Y;Zhang HK
声学分辨率光声显微镜(AR-PAM)的最新配置体积大、价格昂贵，阻碍了它们的民主化。虽然以前关于AR-PAM的研究引入了低成本的光源来降低成本，但很少有研究探讨优化传感器驱动的可能性，特别是对于AR-PAM。此外，还有一个未得到满足的需求，即评估与驱动不准确相关的图像质量恶化。为了减小AR-PAM的系统体积和成本，同时通过采用先进的波束形成器来保持图像质量，引入了一种低成本的驱动装置。这项工作提出了一种AR-RAM，其中包含了Delta配置的致动器，该致动器可以从低成本的现成3D打印机中适配，作为传感器驱动装置。在仿真中对数据采集定位不准确造成的图像质量下降进行了评估。我们进一步评估了以带相干因子的延迟相加(DAS+CF)算法和延迟相乘相加(DMAS)算法为代表的先进3D合成孔径聚焦算法对潜在驱动精度不确定性的缓解。仿真研究验证了图像质量对运动误差的容忍度，以及通过先进的重建算法补偿驱动器运动精度误差的效果。使用这些算法，在存在0.2 mm运动误差的情况下，图像质量降级被抑制到25%以内。使用体模和体外样本进行的实验评估表明，低成本的Delta结构执行器适用于AR-PAM。应用DAS算法、DAS+CF算法和DMAS算法测得直径为0.2 mm的铅笔-铅芯模型的半高宽分别为0.45±0.06 mm、0.31±0.04 mm和0.35±0.07 mm。AR-PAM具有紧凑和低成本的Delta配置，为生物医学应用提供了更好的可及性，提供了高质量的PA成像。这项研究评估了由驱动误差造成的图像退化，并表明先进的波束形成器能够抑制驱动误差。
The state-of-the-art configurations for acoustic-resolution photoacoustic (PA) microscope (AR-PAM) are large in size and expensive, hindering their democratization. While previous research on AR-PAMs introduced a low-cost light source to reduce the cost, few studies have investigated the possibility of optimizing the sensor actuation, particularly for the AR-PAM. Additionally, there is an unmet need to evaluate the image quality deterioration associated with the actuation inaccuracy. A low-cost actuation device is introduced to reduce the system size and cost of the AR-PAM while maintaining the image quality by implementing the advanced beamformers. This work proposes an AR-RAM incorporating the delta configuration actuator adaptable from a low-cost off-the-shelf 3D printer as the sensor actuation device. The image degradation due to the data acquisition positioning inaccuracy is evaluated in the simulation. We further assess the mitigation of potential actuation precision uncertainty through advanced 3D synthetic aperture focusing algorithms represented by the Delay-and-Sum (DAS) with Coherence Factor (DAS+CF) and Delay-Multiply-and-Sum (DMAS) algorithms. The simulation study demonstrated the tolerance of image quality on actuation inaccuracy and the effect of compensating the actuator motion precision error through advanced reconstruction algorithms. With those algorithms, the image quality degradation was suppressed to within 25% with the presence of 0.2 mm motion inaccuracy. The experimental evaluation using phantoms and an ex-vivo sample presented the applicability of low-cost delta configuration actuators for AR-PAMs. The measured full width at half maximum of the 0.2 mm diameter pencil-lead phantom were 0.45±0.06 mm, 0.31±0.04 mm, and 0.35±0.07 mm, by applying the DAS, DAS+CF, and DMAS algorithms, respectively. AR-PAMs with a compact and low-cost delta configuration provide high-quality PA imaging with better accessibility for biomedical applications. The research evaluated the image degradation contributed by the actuation inaccuracy and suggested that the advanced beamformers are capable of suppressing the actuation inaccuracy.
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DOI：
10.3389/fnene.2010.00010
发表时间：
2010
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
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影响因子：
3.6
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