Determinants of polycyclic aromatic hydrocarbon levels in house dust.
Determinants of polycyclic aromatic hydrocarbon levels in house dust.
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DOI：
10.1038/jes.2009.68
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发表时间：
2011-03
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
估计人类对多环芳烃(PAHs)的暴露常常是癌症流行病学研究所需要的。获取室内多环芳烃水平信息的一种方法是测量房屋灰尘中的这些化学物质。在这项研究中，我们评估了自报数据和地理数据在估计北加州儿童白血病研究(NCCLS)583个家庭的房屋灰尘中九种多环芳烃测量水平的预测价值。利用多元线性回归模型，我们评估了以下协变量对室内粉尘多环芳烃浓度的影响：住宅加热源、吸烟习惯、房屋特征和室外排放源。2001年至2007年，使用大容量表面采样器和家用真空吸尘器收集了房屋粉尘，并使用气相色谱-质谱仪对9种多环芳烃进行了分析。所有9种多环芳烃都在93%以上的粉尘样本中检测到，中位数浓度在14至94 ng/g粉尘之间。燃气加热、室外多环芳烃浓度和居住年限对室内粉尘中的多环芳烃浓度有统计学意义的影响。然而，最优回归模型仅解释了室内粉尘中多环芳烃水平变化的15%。由于自行报告的数据和室外多环芳烃来源对观察到的多环芳烃水平仅有微弱的预测作用，我们建议在流行病学研究中直接测量粉尘样本中的多环芳烃浓度。
Estimation of human exposures to polycyclic aromatic hydrocarbons (PAHs) is often desired for the epidemiological studies of cancer. One way to obtain information about indoor levels of PAHs is to measure these chemicals in house dust. In this study, we evaluated the predictive value of self-reported and geographic data for estimating measured levels of nine PAHs in house dust from 583 households in the Northern California Childhood Leukemia Study (NCCLS). Using multivariable linear regression models, we evaluated the effects on house-dust PAH concentrations from the following covariates: residential heating sources, smoking habits, house characteristics, and outdoor emission sources. House dust was collected from 2001 to 2007, usingboth high-volume surface samplers and household vacuum cleaners, and was analyzed for nine PAHs using gas chromatography-mass spectrometry. All nine PAHs were detected in more than 93% of dust samples, with median concentrations ranging from 14 to 94 ng/g dust. Statistically significant effects on PAH concentrations in house dust were found for gas heating, outdoor PAH concentrations, and residence age. Yet, the optimal regression model only explained 15% of the variation in PAH levels in house dust. As self-reported data and outdoor PAH sources were only marginally predictive of observed PAH levels, we recommend that PAH concentrations be measured directly in dust samples for use in epidemiological studies.
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用于重建历史暴露于多环芳烃的模型的验证和校准，用于流行病学研究。
影响因子：
10.4
作者：
Beyea, Jan;Hatch, Maureen;Stellman, Steven D;Santella, Regina M;Teitelbaum, Susan L;Prokopczyk, Bogdan;Camann, David;Gammon, Marilie D
通讯作者：
Gammon, Marilie D
影响因子：
10.4
作者：
Choi H;Rauh V;Garfinkel R;Tu Y;Perera FP
通讯作者：
Perera FP
影响因子：
10.4
作者：
Lubin JH;Colt JS;Camann D;Davis S;Cerhan JR;Severson RK;Bernstein L;Hartge P
通讯作者：
Hartge P
影响因子：
--
作者：
Burstyn, I;Kromhout, H;Boffetta, P
通讯作者：
Boffetta, P
DOI：
10.1007/s00244-006-0261-6
发表时间：
2007-11-01
影响因子：
4
作者：
Gevao, Bondi;Al-Bahloul, Majed;Helaleh, Murad
通讯作者：
Helaleh, Murad