Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis.
Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis.
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DOI：
10.1007/s00330-017-5140-1
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发表时间：
2018-05
影响因子：
5.9
通讯作者：
Eckstein F
中科院分区：
文献类型：
--
作者：
Roth M;Emmanuel K;Wirth W;Kwoh CK;Hunter DJ;Eckstein F
确定3D关节测量对纵向变化的敏感性是否与软骨厚度相似;这些测量与纵向关节间隙宽度（JSW）变化的相关程度;以及最小（mJSW）和固定位置JSW之间的后一种关联是否不同。确定了3 - 5例Osteoarthritis Initiative膝关节[12例男性，年龄：67（51-77）岁; 23例女性，年龄：65（54-78）岁]的内侧关节位置和形态、软骨厚度（MRI）以及最小和固定位置JSW（X线摄影）的2年变化，这些膝关节在3-5年内从基线Kelling-Lawrence分级≤2级进展至膝关节置换术。多元线性回归评估了导致JSW变化的特征。半月板测量、软骨厚度和JSW显示出相似的变化敏感性（标准化反应平均值≤| 0.76|).半月板变化与JSW变化密切相关（r≤| 0.66|），除了软骨厚度变化之外，其方差增加≤20%。固定位置JSW变化（多个r2=72%）与软骨和关节变化的相关性比mJSW（61%）更强。半月板形态对固定位置JSW的解释力更强，半月板位置对mJSW的解释力更强。半月板测量提供独立的信息来解释影像学JSW变化的差异。固定位置的JSW似乎比mJSW更能反映结构变化，因此是结构进展的潜在上级指标。·快速进展的膝关节中的3D位置/形态学测量变化。 ·在快速进展中，对定量骨/软骨测量的2年变化的敏感性相似。 ·影像学测量的变化与影像学JSW变化密切相关。 ·半月板变化提供了解释独立于软骨的JSW变化的信息。 ·固定位置JSW比最小JSW更接近地反映结构性疾病阶段。
To determine whether 3D meniscal measures had similar sensitivity to longitudinal change as cartilage thickness; to what extent these measures are associated with longitudinal joint space width (JSW) change; and whether the latter associations differ between minimum (mJSW) and fixed-location JSW. Two-year changes in medial meniscal position and morphology, cartilage thickness (MRI) and minimum and fixed-location JSW (radiography) were determined in 35 Osteoarthritis Initiative knees [12 men, age: 67 (51-77) years; 23 women, age: 65 (54-78) years], progressing from baseline Kellgren-Lawrence grade ≤2 to knee replacement within 3-5 years. Multiple linear regression assessed the features contributing to JSW change. Meniscal measures, cartilage thickness and JSW displayed similar sensitivity to change (standardised response mean≤|0.76|). Meniscal changes were strongly associated with JSW change (r≤|0.66|), adding ≤20% to its variance in addition to cartilage thickness change. Fixed-location JSW change (multiple r2=72%) was more strongly related to cartilage and meniscal change than mJSW (61%). Meniscal morphology explained more of fixed-location JSW and meniscal position more of mJSW. Meniscal measures provide independent information in explaining the variance of radiographic JSW change. Fixed-location JSW appears to be more reflective of structural change than mJSW and, hence, a potentially superior measure of structural progression. • 3D positional/morphological meniscal measures change in rapidly progressing knees. • Similar sensitivity to 2-year change of quantitative meniscal/cartilage measures in rapid progression. • Changes in meniscal measures are strongly associated with radiographic JSW change. • Meniscal change provides information to explain JSW variance independent of cartilage. • Fixed-location JSW reflects structural disease stage more closely than minimum JSW.
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影响因子：
7
作者：
Peterfy CG;Schneider E;Nevitt M
通讯作者：
Nevitt M
影响因子：
5.9
作者：
Eckstein F;Boudreau R;Wang Z;Hannon MJ;Duryea J;Wirth W;Cotofana S;Guermazi A;Roemer F;Nevitt M;John MR;Ladel C;Sharma L;Hunter DJ;Kwoh CK;OAI Investigators
通讯作者：
OAI Investigators
影响因子：
4.7
作者：
Duryea, Jeffrey;Neumann, Gesa;Niu, Jingbo;Totterman, Saara;Tamez, Jose;Dabrowski, Christine;Le Graverand, Marie-Pierre Hellio;Luchi, Monica;Beals, Chan R.;Hunter, David J.
通讯作者：
Hunter, David J.
影响因子：
7
作者：
Hunter, D. J.;Buck, R.;Le Graverand, M. P. Hellio
通讯作者：
Le Graverand, M. P. Hellio
影响因子：
3.3
作者：
Wirth, Wolfgang;Frobell, Richard B.;Eckstein, Felix
通讯作者：
Eckstein, Felix