A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson's disease.
A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson's disease.
复制标题
DOI：
10.1016/j.prdoa.2021.100104
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Jacobs JP
中科院分区：
文献类型：
--
作者：
Jones JD;Dominguez B;Bunch J;Uribe C;Valenzuela Y;Jacobs JP
胃肠道（GI）和情绪症状在帕金森病中很常见。抑郁和焦虑是胃肠道痛苦的双向危险因素。胃肠道和情绪症状之间的联系可能反映了肠-脑轴的中断。焦虑、抑郁和胃肠道（GI）症状是帕金森病（PD）常见的非运动症状。过去的研究提供了PD中微生物组-肠-脑轴被破坏的证据，这与PD中的某些运动和非运动症状有关。此外，有证据表明，在胃肠道疾病患者中，心理健康和肠道健康之间存在双向关联。目前的研究调查了新诊断为PD的个体中胃肠道症状与焦虑/抑郁之间的双向关联。我们对帕金森进展标志物计划进行了二次数据分析。其中包括487名新诊断为PD的患者，随访时间长达5年。参与者在每次年度就诊时完成焦虑、抑郁和胃肠道症状问卷（帕金森病自主预后量表；SCOPA-AUT）。多水平模型检验了胃肠道症状与焦虑/抑郁之间的双向滞后关系。模型为胃肠道症状与焦虑/抑郁之间的双向关系提供了证据。具体来说，更严重的胃肠道症状预示着更严重的焦虑/抑郁症状在同一年和第二年。也有证据表明这种反向性，这意味着更严重的焦虑/抑郁预示着更严重的胃肠道症状同时发生和在接下来的一年。研究结果为PD患者肠道健康和心理健康之间的周期性关系提供了初步证据。未来的研究需要检查微生物群-肠-脑轴是否起机制作用。
Gastrointestinal (GI) and mood symptoms are common in Parkinson’s disease. Depression and anxiety are bidirectional risk factors for GI distress. Association between GI and mood symptoms may reflect disrupted Gut-Brain axis. Anxiety, depression and gastrointestinal (GI) symptoms are common non-motor symptoms in Parkinson’s disease (PD). Past studies provide evidence of a disrupted microbiome-gut-brain axis in PD, which is associated with certain motor and non-motor symptoms in PD. Additionally, there is evidence of a bidirectional association between mental health and gut health among individuals with GI disorders. The current study examined the bidirectional association between GI symptoms and anxiety/depression among individuals newly diagnosed with PD. We conducted a secondary data analysis of the Parkinson’s Progression Markers Initiative. This included 487 individuals newly diagnosed with PD and followed for up to 5 years. Participants completed questionnaires of anxiety, depression and GI symptoms (Scales for Outcomes in Parkinson’s Disease Autonomic; SCOPA-AUT) at each annual visit. Multilevel models examined the bidirectional-lagged relationship between GI symptoms and anxiety/depression. Models provided evidence for a bidirectional relationship between GI symptoms and anxiety/depression. Specifically, more severe GI symptoms predicted more severe anxious/depressive symptoms within the same year and at the following year. There was also evidence of the inverse directionality, meaning that more severe anxiety/depression predicted more severe GI symptoms concurrently and in the following year. Findings provide preliminary evidence for a cyclical relationship among gut health and mental health in PD. Future studies are needed to examine if the microbiome-gut-brain axis plays a mechanistic role.
登录
查看更多内容
DOI：
10.1002/mds.27105
发表时间：
2018-01
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Heintz-Buschart A;Pandey U;Wicke T;Sixel-Döring F;Janzen A;Sittig-Wiegand E;Trenkwalder C;Oertel WH;Mollenhauer B;Wilmes P
通讯作者：
Wilmes P
影响因子：
8.6
作者：
Pontone, Gregory M.;Williams, James R.;Anderson, Karen E.;Chase, Gary;Goldstein, Susanne A.;Grill, Stephen;Hirsch, Elaina S.;Lehmann, Susan;Little, John T.;Margolis, Russell L.;Rabins, Peter V.;Weiss, Howard D.;Marsh, Laura
通讯作者：
Marsh, Laura
影响因子：
6
作者：
Picillo M;Palladino R;Erro R;Alfano R;Colosimo C;Marconi R;Antonini A;Barone P;PRIAMO study group
通讯作者：
PRIAMO study group
影响因子：
6.8
作者：
Allen AP;Hutch W;Borre YE;Kennedy PJ;Temko A;Boylan G;Murphy E;Cryan JF;Dinan TG;Clarke G
通讯作者：
Clarke G
影响因子：
15.1
作者：
Jiang, Haiyin;Ling, Zongxin;Ruan, Bing
通讯作者：
Ruan, Bing