White matter characterization of adolescent binge drinking with and without co-occurring marijuana use: a 3-year investigation.
White matter characterization of adolescent binge drinking with and without co-occurring marijuana use: a 3-year investigation.
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DOI：
10.1016/j.pscychresns.2013.07.014
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发表时间：
2013-12-30
影响因子：
11.3
通讯作者：
Tapert SF
中科院分区：
文献类型：
--
作者：
Jacobus J;Squeglia LM;Bava S;Tapert SF
这项研究的目的是调查长期饮酒和吸食大麻对青春期后期白质完整性和神经认知功能的影响，并在三年的定期随访中检查神经发育轨迹。三组人口统计学上相似的青少年每1.5年接受一次评估（一贯很少使用物质的对照组，n = 16；逐渐增加大量间歇性饮酒的青少年，n = 17；持续大量使用大麻的酗酒者，n = 21），包括全面的神经心理学评估、扩散张量成像和详细的物质使用访谈。单因素方差分析确定了15个白质簇，在3年随访中，年龄在19-22岁之间；对照组一致显示纤维束的组织完整性更高。重复测量方差分析显示，从基线到3年随访，物质使用者亚样本的白质完整性显著下降，同时在18个月的随访中，大量使用大麻的酒精使用者的整体神经认知表现较差。研究结果表明，没有大量饮酒和吸食大麻的青少年大脑白质结构更健康，神经认知能力更好。长期接触这些物质可能会对白质产生不利影响，并增加神经病理学发展的脆弱性，据称这是未来冒险和成瘾行为的基础。
The aims of this study were to investigate the consequences of prolonged patterns of alcohol and marijuana use on white matter integrity and neurocognitive functioning in late adolescence, and examine neurodevelopmental trajectories over three years of regular follow-up visits. Three groups of demographically similar teens received assessments every 1.5 years (controls with consistently minimal substance use, n = 16; teens who gradually increase their heavy episodic drinking n = 17, and continuous binge drinkers with heavy marijuana use, n = 21), including comprehensive neuropsychological evaluations, diffusion tensor imaging, and detailed substance use interviews. One-way ANOVA identified fifteen white matter clusters that significantly differed between groups at 3-year follow-up, ages 19–22; controls consistently demonstrated higher values of tissue integrity across fiber tracts. Repeated measures ANOVA revealed significant declines in white matter integrity from baseline to 3-year follow-up in the subsample of substance users, along with poorer global neurocognitive performance in alcohol users with heavy marijuana use by the 18-month follow-up. Findings suggest healthier brain white matter microstructure and better neurocognitive performance for teens free from heavy alcohol and marijuana use. Long-term engagement in these substances may adversely influence white matter and increase vulnerability for development of neuropathology purported to underlie future risk-taking and addictive behaviors.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
3.7
作者：
Berns GS;Moore S;Capra CM
通讯作者：
Capra CM
影响因子：
2.5
作者：
Bava, Sunita;Jacobus, Joanna;Mahmood, Omar;Yang, Tony T.;Tapert, Susan F.
通讯作者：
Tapert, Susan F.
DOI：
10.15288/jsa.1998.59.427
发表时间：
1998-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Brown, SA;Myers, MG;Vik, PW
通讯作者：
Vik, PW
影响因子：
2.9
作者：
Jacobus, J.;McQueeny, T.;Bava, S.;Schweinsburg, B. C.;Frank, L. R.;Yang, T. T.;Tapert, S. F.
通讯作者：
Tapert, S. F.