White matter integrity in adolescents with histories of marijuana use and binge drinking.
White matter integrity in adolescents with histories of marijuana use and binge drinking.
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DOI：
10.1016/j.ntt.2009.07.006
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发表时间：
2009-11
影响因子：
2.9
通讯作者：
Tapert, S. F.
中科院分区：
文献类型：
--
作者：
Jacobus, J.;McQueeny, T.;Bava, S.;Schweinsburg, B. C.;Frank, L. R.;Yang, T. T.;Tapert, S. F.
在患有酒精使用障碍的青少年中观察到脑结构异常，但对患有亚诊断性酗酒或酗酒与大麻使用相结合的常见模式的青少年的神经病理学脑特征知之甚少。本研究的目的是检查有酗酒和大麻使用史的青少年的白色物质完整性。对42名青少年（年龄16 - 19岁）进行了弥散张量成像（DTI），这些青少年被分为对照组、酗酒者或同时重度吸食大麻的酗酒者。道为基础的空间分析确定了共享的纤维结构在个人和促进组间的分数各向异性（FA）和平均扩散率（MD）的voxelwise比较。在8个白色区域（ps ≤ 0.016）的FA中，在仅狂饮组和对照组之间发现了显著的组间差异，包括上级放射冠、下纵束、下额枕束和上级纵束。有趣的是，在4个相同的地区，酗酒者谁也是重度大麻用户有更高的FA比酗酒者谁没有使用大麻（ps <0.05）。MD在组间没有差异。研究结果在很大程度上与没有物质使用史的青少年神经病理学较少的研究一致。然而，也使用大麻的酗酒者并没有表现出与非使用者一致的分歧，就像只酗酒的人一样。检测白色物质改变可能对识别物质使用青少年的早期认知功能障碍有影响。
Structural brain abnormalities have been observed in adolescents with alcohol use disorders but less is known about neuropathological brain characteristics of teens with subdiagnostic binge drinking or the common pattern of binge drinking combined with marijuana use. The goal of this study was to examine white matter integrity in adolescents with histories of binge drinking and marijuana use. Diffusion tensor imaging (DTI) was conducted with 42 adolescents (ages 16−19) classified as controls, binge drinkers, or binge drinkers who are also heavy marijuana users. Tract based spatial analysis identified shared fiber structure across individuals and facilitated voxelwise comparisons of fractional anisotropy (FA) and mean diffusivity (MD) between groups. Significant between group differences were found in FA in eight white matter regions (ps ≤ .016) between the binge drink-only group and controls, including superior corona radiata, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and superior longitudinal fasciculus. Interestingly, in 4 of these same regions, binge drinkers who are also heavy marijuana users had higher FA than binge drinkers who did not use marijuana (ps < .05). MD did not differ between groups. Findings are largely consistent with research suggesting less neuropathology in adolescents without histories of substance use. However, binge drinkers who also use marijuana did not show as consistent a divergence from non-users as did the binge drink-only group. Detection of white matter alterations may have implications in identifying early cognitive dysfunction in substance using adolescents.
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DOI：
10.1111/j.1530-0277.2007.00603.x
发表时间：
2008-03-01
影响因子：
3.2
作者：
De Bellis, Michael D.;Van Voorhees, Elizabeth;MacFall, James
通讯作者：
MacFall, James
DOI：
10.15288/jsa.1998.59.427
发表时间：
1998-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Brown, SA;Myers, MG;Vik, PW
通讯作者：
Vik, PW
影响因子：
4.8
作者：
Ashtari M;Cervellione K;Cottone J;Ardekani BA;Sevy S;Kumra S
通讯作者：
Kumra S
影响因子：
7.6
作者：
Chanraud, Sandra;Martelli, Catherine;Martinot, Jean-Luc
通讯作者：
Martinot, Jean-Luc
DOI：
10.1097/01.alc.0000179368.87886.76
发表时间：
2005-09-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
De Bellis, Michael D;Narasimhan, Anandhi;Clark, Duncan B
通讯作者：
Clark, Duncan B