Premorbid body mass index and risk of amyotrophic lateral sclerosis.
Premorbid body mass index and risk of amyotrophic lateral sclerosis.
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DOI：
10.3109/21678421.2012.735240
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发表时间：
2013-04
影响因子：
2.8
通讯作者：
Ascherio A
中科院分区：
文献类型：
--
作者：
O'Reilly ÉJ;Wang H;Weisskopf MG;Fitzgerald KC;Falcone G;McCullough ML;Thun M;Park Y;Kolonel LN;Ascherio A
确定肌萎缩性侧索硬化症（ALS）的风险是否根据三十年前采集的体重指数（BMI）而变化。在基线时，5个正在进行的队列中有537，968名女性和562，942名男性报告了身高、当前体重和18/21岁时的体重。在14-28年的随访中，1，153名参与者发展为ALS。队列特异性考克斯比例风险模型用于估计率，然后与随机效应模型合并。基线时较低的BMI与ALS相关; BMI每增加5个单位，ALS发生率降低21%（95%CI：14%至27%）。与BMI健康的个体相比，超重（RR=0.76 [95%CI：0.62-0.93]）和肥胖（RR=0.73 [95%CI：0.55-0.96]）的ALS发生率显著降低。在从不吸烟者中，这种关联持续存在：每增加5个单位，RR=0.75（95%CI：0.65-0.85）。排除前七年的随访，这些关联基本上没有变化，表明未确诊疾病的体重减轻并不能完全解释这些发现。总体而言，75%的男性和女性在18/21岁时具有健康的BMI，15%的男性和8%的女性超重或肥胖;尽管力量有限，但与ALS风险无关。这些发现支持了较低的病前BMI和ALS之间的关联。
To determine if Amyotrophic Lateral Sclerosis (ALS) risk varies according to body mass index (BMI) captured up to three decades earlier. At baseline 537,968 women and 562,942 men in five ongoing cohorts reported height, current weight and weight at age 18/21. During 14-28 years of follow-up 1,153 participants developed ALS. Cohort-specific Cox proportional hazards models were used to estimate rates that were then pooled with random effects models. Lower BMI at baseline was associated with ALS; for each 5-unit increase in BMI, ALS rates were 21% lower (95%CI: 14% to 27%). Compared to individuals with healthy BMI, ALS rates were significantly lower among the overweight (RR=0.76 [95%CI: 0.62-0.93]) and obese (RR=0.73 [95%CI: 0.55-0.96]). Among never-smokers the association persisted: RR=0.75 (95%CI: 0.65-0.85) for each 5-unit increase. Excluding the first seven years of follow-up, the associations were materially unchanged suggesting that weight loss from undiagnosed disease does not fully explain the findings. Overall, 75% of men and women had a healthy BMI at age 18/21, 15% of men and 8% of women were overweight or obese; there was no association with ALS risk although power was limited. These findings support an association between lower premorbid BMI and ALS.
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影响因子：
5
作者：
Nelson, LM;McGuire, V;Matkin, C
通讯作者：
Matkin, C
影响因子：
168.9
作者：
RIMM, EB;GIOVANNUCCI, EL;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
影响因子：
5
作者：
Weisskopf, MG;McCullough, ML;Ascherio, A
通讯作者：
Ascherio, A
影响因子：
--
作者：
Longstreth, WT;McGuire, V;van Belle, G
通讯作者：
van Belle, G
影响因子：
9.9
作者：
Scarmeas, N;Shih, T;Rowland, LP
通讯作者：
Rowland, LP