Translating stem cell therapies: the role of companion animals in regenerative medicine.
Translating stem cell therapies: the role of companion animals in regenerative medicine.
复制标题
转化干细胞疗法：伴侣动物在再生医学中的作用。
DOI：
10.1111/wrr.12044
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Theoret C
中科院分区：
文献类型：
--
作者：
Volk SW;Theoret C
兽医和兽医医学对于干细胞疗法的发展至关重要。近五年前，大型动物实验模型对现代造血干细胞移植的发展和完善的贡献就已被注意到。成体干细胞/再生细胞疗法的最新进展继续扩大干细胞的基础生物学和临床应用知识。兽医干细胞研究相对自由的法律和伦理监管促进了各种基于细胞的疗法的开发和在某些情况下的临床转化，涉及造血（HSC）和间充质干细胞（MSC）以及其他成体再生细胞和最近的胚胎干细胞（ESC）和诱导多能干细胞（iPSC）。事实上，干细胞研究这些领域的许多开创性发展都是通过兽医和人类科学家的合作实现的。本综述旨在概述大型动物兽医模型在推动人类和临床兽医应用干细胞疗法方面的贡献。此外，在“同一个健康倡议”的背景下，将探讨兽医患者在人类和动物患者干细胞疗法的未来发展中可能发挥的作用。
Veterinarians and veterinary medicine have been integral to the development of stem cell therapies. The contributions of large animal experimental models to the development and refinement of modern hematopoietic stem cell transplantation were noted nearly five decades ago. More recent advances in adult stem cell/regenerative cell therapies continue to expand knowledge of the basic biology and clinical applications of stem cells. A relatively liberal legal and ethical regulation of stem cell research in veterinary medicine has facilitated the development and in some instances clinical translation of a variety of cell-based therapies involving hematopoietic (HSC) and mesenchymal stem cells (MSC) as well as other adult regenerative cells and recently embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). In fact, many of the pioneering developments in these fields of stem cell research have been achieved through collaborations of veterinary and human scientists. This review aims to provide an overview of the contribution of large animal veterinary models in advancing stem cell therapies for both human and clinical veterinary applications. Moreover, in the context of the “One Health Initiative”, the role veterinary patients may play in the future evolution of stem cell therapies for both human and animal patients will be explored.
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