Circadian clock synchrony and chronotherapy opportunities in cancer treatment.
Circadian clock synchrony and chronotherapy opportunities in cancer treatment.
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DOI：
10.1016/j.semcdb.2021.07.017
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发表时间：
2022-06
影响因子：
7.3
通讯作者：
Herzog ED
中科院分区：
文献类型：
--
作者：
Damato AR;Herzog ED
在整个人体中都观察到了基因表达和细胞过程中细胞自主的、组织特异性的昼夜节律。由于不合时宜的光照、食物摄入或基因突变而扰乱日常节律与癌症的发生有关。有些药物在一天中的某些时间也更有效。然而，有限数量的临床研究检查了患者的日常节律或药物时机作为治疗策略。这篇综述强调了癌症生物学随时间变化的进展和挑战。最近关于日常节律及其在肿瘤中的夹带的证据表明，个性化医疗应包括理解和解释癌症患者的日常节律。
Cell-autonomous, tissue-specific circadian rhythms in gene expression and cellular processes have been observed throughout the human body. Disruption of daily rhythms by mistimed exposure to light, food intake, or genetic mutation has been linked to cancer development. Some medications are also more effective at certain times of day. However, a limited number of clinical studies have examined daily rhythms in the patient or drug timing as treatment strategies. This review highlights advances and challenges in cancer biology as a function of time of day. Recent evidence for daily rhythms and their entrainment in tumors indicate that personalized medicine should include understanding and accounting for daily rhythms in cancer patients.
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影响因子：
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