Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study.
Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study.
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DOI：
10.3389/fnhum.2017.00446
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发表时间：
2017
影响因子：
2.9
通讯作者：
Taniike M
中科院分区：
文献类型：
--
作者：
Matsuzaki J;Kagitani-Shimono K;Sugata H;Hanaie R;Nagatani F;Yamamoto T;Tachibana M;Tominaga K;Hirata M;Mohri I;Taniike M
虽然异常听觉敏感性是自闭症谱系障碍（ASD）最常见的感觉障碍，但其神经生理机制尚不清楚。在以前的研究中，我们报道了ASD患者的这种异常敏感性与听觉皮层的延迟和延长反应有关。在本研究中，我们调查了听觉灵敏度异常的ASD儿童的残余M100和MMF的变化。我们使用脑磁图（MEG）来测量由听觉oddball范式引起的MMF标准音300 Hz，异常音700 Hz（11例听觉灵敏度异常：平均年龄，9.62 ± 1.82岁，9例无：13例发育正常的男孩，平均年龄9.45 ± 1.51岁。我们发现，颞叶和额叶残留的M100/MMF潜伏期显着较长，只有儿童ASD谁有异常的听觉灵敏度。此外，延长的残留M100/MMF潜伏期与两半球颞叶和额叶听觉敏感度异常的严重程度相关。因此，我们的研究结果表明，ASD和异常的听觉灵敏度的儿童可能有非典型的神经网络在初级听觉区，以及在大脑区域与注意力转换和抑制控制处理。这是MEG研究的第一份报告，证明了改变的MMF在ASD和异常听觉敏感性患者中的听觉古怪范式。这些发现有助于了解ASD异常听觉敏感性的机制，因此可能有助于开发新的临床干预措施。
Although abnormal auditory sensitivity is the most common sensory impairment associated with autism spectrum disorder (ASD), the neurophysiological mechanisms remain unknown. In previous studies, we reported that this abnormal sensitivity in patients with ASD is associated with delayed and prolonged responses in the auditory cortex. In the present study, we investigated alterations in residual M100 and MMFs in children with ASD who experience abnormal auditory sensitivity. We used magnetoencephalography (MEG) to measure MMF elicited by an auditory oddball paradigm (standard tones: 300 Hz, deviant tones: 700 Hz) in 20 boys with ASD (11 with abnormal auditory sensitivity: mean age, 9.62 ± 1.82 years, 9 without: mean age, 9.07 ± 1.31 years) and 13 typically developing boys (mean age, 9.45 ± 1.51 years). We found that temporal and frontal residual M100/MMF latencies were significantly longer only in children with ASD who have abnormal auditory sensitivity. In addition, prolonged residual M100/MMF latencies were correlated with the severity of abnormal auditory sensitivity in temporal and frontal areas of both hemispheres. Therefore, our findings suggest that children with ASD and abnormal auditory sensitivity may have atypical neural networks in the primary auditory area, as well as in brain areas associated with attention switching and inhibitory control processing. This is the first report of an MEG study demonstrating altered MMFs to an auditory oddball paradigm in patients with ASD and abnormal auditory sensitivity. These findings contribute to knowledge of the mechanisms for abnormal auditory sensitivity in ASD, and may therefore facilitate development of novel clinical interventions.
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影响因子：
4.8
作者：
Floris DL;Lai MC;Auer T;Lombardo MV;Ecker C;Chakrabarti B;Wheelwright SJ;Bullmore ET;Murphy DG;Baron-Cohen S;Suckling J
通讯作者：
Suckling J
影响因子：
2.9
作者：
Edgar JC;Lanza MR;Daina AB;Monroe JF;Khan SY;Blaskey L;Cannon KM;Jenkins J 3rd;Qasmieh S;Levy SE;Roberts TP
通讯作者：
Roberts TP
影响因子：
6.2
作者：
Edgar JC;Fisk Iv CL;Berman JI;Chudnovskaya D;Liu S;Pandey J;Herrington JD;Port RG;Schultz RT;Roberts TP
通讯作者：
Roberts TP
影响因子：
5.3
作者：
Cai, Weidong;Ryali, Srikanth;Menon, Vinod
通讯作者：
Menon, Vinod
影响因子：
3.7
作者：
Galilee A;Stefanidou C;McCleery JP
通讯作者：
McCleery JP