Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions.
Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions.
复制标题
在旅行限制期间，区域连通性推动了中东SARS-COV-2的双向传播。
DOI：
10.1038/s41467-022-32536-1
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发表时间：
2022-08-15
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
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作者：
区域连通性和陆路旅行已被确定为SARS-CoV-2传播的重要驱动因素。然而，这一发现的普遍性在采样良好、高度连通的区域之外还没有得到充分研究。在这项研究中，我们调查了区域和洲际连通性对约旦和中东SARS-CoV-2源-汇动态的相对贡献。通过整合基因组、流行病学和旅行数据，我们发现，2020年引入约旦的来源是动态的，从大流行早期的洲际传播转向旅行限制期间的区域传播。我们发现，在旅行限制期间，陆地旅行，特别是货运，推动引进风险。高度的区域连通性和陆路旅行也增加了约旦的出口风险。我们的研究结果强调，区域连通性和陆地旅行是中东地区传播的驱动因素。SARS-CoV-2在中东的传播动力学研究相对不足。在这里，作者整合了基因组和旅行数据，并表明该地区的引入最初是由洲际航空旅行驱动的，之后区域陆地旅行成为更重要的驱动力。
Regional connectivity and land travel have been identified as important drivers of SARS-CoV-2 transmission. However, the generalizability of this finding is understudied outside of well-sampled, highly connected regions. In this study, we investigated the relative contributions of regional and intercontinental connectivity to the source-sink dynamics of SARS-CoV-2 for Jordan and the Middle East. By integrating genomic, epidemiological and travel data we show that the source of introductions into Jordan was dynamic across 2020, shifting from intercontinental seeding in the early pandemic to more regional seeding for the travel restrictions period. We show that land travel, particularly freight transport, drove introduction risk during the travel restrictions period. High regional connectivity and land travel also drove Jordan’s export risk. Our findings emphasize regional connectedness and land travel as drivers of transmission in the Middle East. The dynamics of SARS-CoV-2 transmission in the Middle East have been relatively under-studied. Here, the authors integrate genomic and travel data and show that introductions to the region were initially driven by intercontinental air travel, after which regional land travel became a more important driver.
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DOI：
10.1016/j.ijid.2020.12.049
发表时间：
2021-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Al-Mahruqi S;Al-Wahaibi A;Khan AL;Al-Jardani A;Asaf S;Alkindi H;Al-Kharusi S;Al-Rawahi AN;Al-Rawahi A;Al-Salmani M;Al-Shukri I;Al-Busaidi A;Al-Abri SS;Al-Harrasi A
通讯作者：
Al-Harrasi A
影响因子：
16.6
作者：
Butera Y;Mukantwari E;Artesi M;Umuringa JD;O'Toole ÁN;Hill V;Rooke S;Hong SL;Dellicour S;Majyambere O;Bontems S;Boujemla B;Quick J;Resende PC;Loman N;Umumararungu E;Kabanda A;Murindahabi MM;Tuyisenge P;Gashegu M;Rwabihama JP;Sindayiheba R;Gikic D;Souopgui J;Ndifon W;Rutayisire R;Gatare S;Mpunga T;Ngamije D;Bours V;Rambaut A;Nsanzimana S;Baele G;Durkin K;Mutesa L;Rujeni N
通讯作者：
Rujeni N
影响因子：
4.6
作者：
Tayoun AA;Loney T;Khansaheb H;Ramaswamy S;Harilal D;Deesi ZO;Varghese RM;Al Suwaidi H;Alkhajeh A;AlDabal LM;Uddin M;Hamoudi R;Halwani R;Senok A;Hamid Q;Nowotny N;Alsheikh-Ali A
通讯作者：
Alsheikh-Ali A
DOI：
10.1126/science.abf2946
发表时间：
2021-02-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
du Plessis L;McCrone JT;Zarebski AE;Hill V;Ruis C;Gutierrez B;Raghwani J;Ashworth J;Colquhoun R;Connor TR;Faria NR;Jackson B;Loman NJ;O'Toole Á;Nicholls SM;Parag KV;Scher E;Vasylyeva TI;Volz EM;Watts A;Bogoch II;Khan K;COVID-19 Genomics UK (COG-UK) Consortium;Aanensen DM;Kraemer MUG;Rambaut A;Pybus OG
通讯作者：
Pybus OG
影响因子：
16.6
作者：
Dudas G;Hong SL;Potter BI;Calvignac-Spencer S;Niatou-Singa FS;Tombolomako TB;Fuh-Neba T;Vickos U;Ulrich M;Leendertz FH;Khan K;Huber C;Watts A;Olendraitė I;Snijder J;Wijnant KN;Bonvin AMJJ;Martres P;Behillil S;Ayouba A;Maidadi MF;Djomsi DM;Godwe C;Butel C;Šimaitis A;Gabrielaitė M;Katėnaitė M;Norvilas R;Raugaitė L;Koyaweda GW;Kandou JK;Jonikas R;Nasvytienė I;Žemeckienė Ž;Gečys D;Tamušauskaitė K;Norkienė M;Vasiliūnaitė E;Žiogienė D;Timinskas A;Šukys M;Šarauskas M;Alzbutas G;Aziza AA;Lusamaki EK;Cigolo JM;Mawete FM;Lofiko EL;Kingebeni PM;Tamfum JM;Belizaire MRD;Essomba RG;Assoumou MCO;Mboringong AB;Dieng AB;Juozapaitė D;Hosch S;Obama J;Ayekaba MO;Naumovas D;Pautienius A;Rafaï CD;Vitkauskienė A;Ugenskienė R;Gedvilaitė A;Čereškevičius D;Lesauskaitė V;Žemaitis L;Griškevičius L;Baele G
通讯作者：
Baele G