Role of Spillover and Spillback in SARS-CoV-2 Transmission and the Importance of One Health in Understanding the Dynamics of the COVID-19 Pandemic.
Role of Spillover and Spillback in SARS-CoV-2 Transmission and the Importance of One Health in Understanding the Dynamics of the COVID-19 Pandemic.
复制标题
溢出和溢出在SARS-CoV-2传播中的作用以及同一健康在理解新冠肺炎大流行动态中的重要性。
DOI：
10.1128/jcm.01610-22
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发表时间：
2023-07-20
影响因子：
9.4
通讯作者：
中科院分区：
文献类型：
--
作者：
严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）对全球公共卫生的影响以及众所周知的对其他动物的传播能力都值得注意。偶然动物宿主的感染是令人担忧的，因为由于病毒突变可能出现新的变异。对SARS-CoV-2易感的物种包括家养和非家养猫、家养狗、白尾鹿、水貂和金仓鼠等。我们详细介绍了SARS-CoV-2向人类传播的可能起源，以及该病毒从动物在人类中建立感染所需的生态和分子机制。我们重点介绍了SARS-CoV-2外溢、外溢和二次外溢的例子，展示了在家养、圈养和野生动物中记录的宿主变异性和当前传播事件的广度。最后，我们将重点放在动物宿主作为可能对人类种群产生深远影响的变异出现的潜在宿主和来源的重要性上。我们注意到，鼓励采用“同一个健康”方法，强调利用跨学科合作对某些环境中的动物和人类进行监测，以管理疾病监测、动物贸易和测试监管以及动物疫苗开发，以减轻进一步的疾病暴发。这些努力将最大限度地减少SARS-CoV-2的传播，并提高预防未来新发传染病传播的知识。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is notable both for its impact on global public health as well as its well-publicized transmissibility to other species of animals. Infection of incidental animal hosts is concerning because of possible emergence of novel variants due to viral mutation. Species that are susceptible to SARS-CoV-2 include domestic and nondomestic cats, domestic dogs, white-tailed deer, mink, and golden hamsters, among others. We detail possible origins of transmission of SARS-CoV-2 to humans, as well as the ecological and molecular mechanisms needed for the virus to establish infection in humans from animals. We highlight examples of SARS-CoV-2 spillover, spillback, and secondary spillover, demonstrating the breadth in the variability of hosts and current transmission events that have been documented in domestic, captive, and wild animals. Lastly, we turn our focus to the importance of animal hosts as potential reservoirs and sources of variant emergence that can have profound effects on the human population. We note that a One Health approach emphasizing surveillance of animals and humans in certain environments using interdisciplinary collaboration is encouraged to manage disease surveillance, regulation on animal trade and testing, and animal vaccine development that will mitigate further disease outbreaks. These efforts will minimize the spread of SARS-CoV-2 and advance knowledge to prevent the spread of future emerging infectious diseases.
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影响因子：
64.8
作者：
Eby, Peggy;Peel, Alison J.;Hoegh, Andrew;Madden, Wyatt;Giles, John R.;Hudson, Peter J.;Plowright, Raina K.
通讯作者：
Plowright, Raina K.
影响因子：
4.3
作者：
Hobbs EC;Reid TJ
通讯作者：
Reid TJ
DOI：
10.1073/pnas.2114828118
发表时间：
2021-11-23
影响因子：
11.1
作者：
Chandler JC;Bevins SN;Ellis JW;Linder TJ;Tell RM;Jenkins-Moore M;Root JJ;Lenoch JB;Robbe-Austerman S;DeLiberto TJ;Gidlewski T;Kim Torchetti M;Shriner SA
通讯作者：
Shriner SA
影响因子：
64.8
作者：
Hale VL;Dennis PM;McBride DS;Nolting JM;Madden C;Huey D;Ehrlich M;Grieser J;Winston J;Lombardi D;Gibson S;Saif L;Killian ML;Lantz K;Tell RM;Torchetti M;Robbe-Austerman S;Nelson MI;Faith SA;Bowman AS
通讯作者：
Bowman AS
影响因子：
3.2
作者：
Francisco R;Hernandez SM;Mead DG;Adcock KG;Burke SC;Nemeth NM;Yabsley MJ
通讯作者：
Yabsley MJ