Association between intrafollicular concentration of benzene and outcome of controlled ovarian stimulation in IVF/ICSI cycles: a pilot study.
Association between intrafollicular concentration of benzene and outcome of controlled ovarian stimulation in IVF/ICSI cycles: a pilot study.
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DOI：
10.1186/1757-2215-7-67
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发表时间：
2014
影响因子：
4
通讯作者：
De Placido G
中科院分区：
文献类型：
--
作者：
Alviggi C;Guadagni R;Conforti A;Coppola G;Picarelli S;De Rosa P;Vallone R;Strina I;Pagano T;Mollo A;Acampora A;De Placido G
一些研究表明，接触苯与月经失调、流产和其他生殖系统疾病有关。我们进行了一项观察性前瞻性初步研究，以评估卵泡液中苯的水平是否与控制性卵巢刺激的反应相关。入组了34例接受IVF的正常促性腺激素女性。通过色谱/质谱法评价卵泡内苯水平。根据苯浓度中位数，我们将研究人群分为两组：A组滤泡内苯浓度“低”（n = 19，苯<0.54 ng/mL）和B组滤泡内苯浓度“高”（n = 15，苯≥ 0.54 ng/mL）。分析两组患者卵巢对促性腺激素的反应性及IVF结局。两组在人口统计学或人体测量学特征方面没有差异。B组基础FSH水平显著高于对照组，雌二醇峰值浓度显著低于对照组，获卵数和移植胚胎数显著低于对照组（p < 0.05）。两组的促性腺激素瓶数、控制性卵巢刺激持续时间和持续妊娠率相似。总之，卵巢对内源性和外源性促性腺激素的反应似乎受到卵泡内苯水平的影响。
Several studies have shown that exposure to benzene is associated to menstrual disorders, miscarriages and other disorders of the reproductive system. We performed an observational prospective pilot study to evaluate if levels of benzene in follicular fluid were correlated with response to controlled ovarian stimulation. Thirty-four normogonadotrophic women undergoing IVF were enrolled. Intra-follicular benzene levels were evaluated by chromatography/mass spectrometry. Based on median benzene level, we divided the study population in two groups: Group A with a “low” intra-follicular benzene concentration (n = 19, benzene <0.54 ng/mL) and Group B with a “high” intra-follicular benzene concentration (n = 15, benzene ≥ 0.54 ng/mL). The ovarian response to gonadotrophins and the outcome of IVF were analyzed in the two groups. The two groups did not differ in terms of demographic or anthropometric characteristics. Group B had significantly higher basal FSH levels, lower estradiol peak concentration, and fewer oocytes retrieved and embryos transferred (p < 0.05). Number of gonadotrophin vials, length of controlled ovarian stimulation and ongoing pregnancy rate were similar in the two groups. In conclusion, ovarian response to endogenous and exogenous gonadotrophins appeared to be influenced by intra-follicular benzene levels.
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影响因子：
10.4
作者：
Choi H;Rauh V;Garfinkel R;Tu Y;Perera FP
通讯作者：
Perera FP
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
DOI：
10.1097/00043764-200106000-00012
发表时间：
2001-06-01
影响因子：
3.2
作者：
Cho, SI;Damokosh, AI;Xu, XP
通讯作者：
Xu, XP
影响因子：
6.7
作者：
De Celis, R;Feria-Velasco, A;Pedrón-Nuevo, N
通讯作者：
Pedrón-Nuevo, N
DOI：
10.1097/00043764-199702000-00011
发表时间：
1997-02-01
影响因子：
3.2
作者：
Smith, EM;HammondsEhlers, M;Fuortes, L
通讯作者：
Fuortes, L