Effects of pedigree errors on the efficiency of conservation decisions.
Effects of pedigree errors on the efficiency of conservation decisions.
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DOI：
10.1186/1297-9686-41-9
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发表时间：
2009-01-14
期刊：
影响因子：
--
通讯作者：
Bijma P
中科院分区：
文献类型：
--
作者：
Oliehoek PA;Bijma P
保护计划通常旨在通过尽量减少亲缘关系来增加遗传多样性，而在可获得谱系数据的情况下，实现这一目标的最佳方法是应用最佳贡献。最佳贡献计算每只动物的贡献，以便候选父母之间的加权平均亲属关系最小化。这种方法假设谱系数据是正确且完整的。然而，在实践中，谱系常常存在错误：父母记录不正确甚至缺失。我们使用模拟来研究这两类错误对最小化亲属关系的影响。我们的研究结果表明，错误父母信息的比例较低会降低最佳贡献的效果。当错误父母信息的百分比高于 15% 时，在应用最佳贡献之前应考虑群体结构和错误类型。基于缺失亲本信息的谱系的最佳贡献阻碍了遗传多样性的保护；但是，缺失的家长信息是可以纠正的。了解哪些动物是创始人至关重要。我们强烈建议血统登记包括失踪父母是否是真正的创始人或非创始人。
Conservation schemes often aim at increasing genetic diversity by minimizing kinship, and the best method to achieve this goal, when pedigree data is available, is to apply optimal contributions. Optimal contributions calculate contributions per animal so that the weighted average mean kinship among candidate parents is minimized. This approach assumes that pedigree data is correct and complete. However, in practice, pedigrees often contain errors: parents are recorded incorrectly or even missing. We used simulations to investigate the effect of these two types of errors on minimizing kinship. Our findings show that a low percentage of wrong parent information reduces the effect of optimal contributions. When the percentage of wrong parent information is above 15%, the population structure and type of errors, should be taken into account before applying optimal contributions. Optimal contributions based on pedigrees with missing parent information hampers conservation of genetic diversity; however, missing parent information can be corrected. It is crucial to know which animals are founders. We strongly recommend that pedigree registration include whether missing parents are either true founders or non-founders.
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