Attention-deficit/hyperactivity disorder without comorbidity is associated with distinct atypical patterns of cerebral microstructural development.
Attention-deficit/hyperactivity disorder without comorbidity is associated with distinct atypical patterns of cerebral microstructural development.
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无合并症的注意力缺陷/多动障碍与大脑微结构发育的独特非典型模式相关。
DOI：
10.1002/hbm.22317
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发表时间：
2014-05
影响因子：
4.8
通讯作者：
Helpern, Joseph A.
中科院分区：
文献类型：
--
作者：
Adisetiyo, Vitria;Tabesh, Ali;Di Martino, Adriana;Falangola, Maria F.;Castellanos, Francisco X.;Jensen, Jens H.;Helpern, Joseph A.
不同的核心症状和治疗反应与注意力缺陷多动障碍（ADHD）的单纯与共病形式有关。然而，在ADHD的神经影像学研究中，共病在很大程度上没有被解释。我们使用弥散峰度成像来研究ADHD儿童和青少年（n = 22）与典型发育对照组（TDC，n = 27）的灰质（GM）和白色（WM）微结构，并检查不同的发育模式是否与合并症有关。ADHD组（混合型ADHD）由伴和不伴共病的亚组组成（ADHD共病组，n = 11; ADHD单纯组，n = 11）。将ADHD混合组和每个ADHD亚组的脑显微结构的脑组织相关变化和组间差异与TDC进行比较。全脑体素为基础的分析与平均峰度（MK）和平均扩散率（MD）的指标进行探测GM和WM。基于道的空间统计分析WM进行MK，MD，分数各向异性，方向（轴向，径向）峰度和扩散率指标。ADHD纯患者缺乏明显的年龄相关的变化，GM和WM的微观结构，观察全球TDC，并有显着更大的WM微观结构的复杂性比TDC在双侧额叶和顶叶，颞叶，胼胝体，和右外和内囊。在分析中包括患有多种合并症的ADHD患者掩盖了这些发现。一个明显的非典型的年龄相关的轨迹和异常的区域差异，在大脑微观结构中检测到ADHD没有合并症。我们的研究结果表明，ADHD的不同表型表现，定义的存在或不存在的合并症，不同的大脑微结构标志物。
Differential core symptoms and treatment responses are associated with the pure versus comorbid forms of attention-deficit/hyperactivity disorder (ADHD). However, comorbidity has largely been unaccounted for in neuroimaging studies of ADHD. We used diffusional kurtosis imaging to investigate gray matter (GM) and white matter (WM) microstructure of children and adolescents with ADHD (n = 22) compared to typically developing controls (TDC, n = 27) and examined whether differing developmental patterns are related to comorbidity. The ADHD group (ADHD-mixed) consisted of subgroups with and without comorbidity (ADHD-comorbid, n = 11; ADHD-pure, n = 11, respectively). Age-related changes and group differences in cerebral microstructure of the ADHD-mixed group and each ADHD subgroup were compared to TDC. Whole-brain voxel-based analyses with mean kurtosis (MK) and mean diffusivity (MD) metrics were conducted to probe GM and WM. Tract-based spatial statistics analyses of WM were performed with MK, MD, fractional anisotropy, and directional (axial, radial) kurtosis and diffusivity metrics. ADHD-pure patients lacked significant age-related changes in GM and WM microstructure that were observed globally in TDC and had significantly greater WM microstructural complexity than TDC in bilateral frontal and parietal lobes, insula, corpus callosum, and right external and internal capsules. Including ADHD patients with diverse comorbidities in analyses masked these findings. A distinct atypical age-related trajectory and aberrant regional differences in brain microstructure were detected in ADHD without comorbidity. Our results suggest that different phenotypic manifestations of ADHD, defined by the presence or absence of comorbidity, differ in cerebral microstructural markers.
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影响因子：
1.7
作者：
Hamilton LS;Levitt JG;O'Neill J;Alger JR;Luders E;Phillips OR;Caplan R;Toga AW;McCracken J;Narr KL
通讯作者：
Narr KL
影响因子：
4.4
作者：
Helpern, Joseph A.;Adisetiyo, Vitria;Falangola, Maria F.;Hu, Caixia;Di Martino, Adriana;Williams, Kathleen;Castellanos, Francisco X.;Jensen, Jens H.
通讯作者：
Jensen, Jens H.
影响因子：
9.9
作者：
Baumgardner, TL;Singer, HS;Reiss, AL
通讯作者：
Reiss, AL
影响因子：
2.3
作者：
Dramsdahl, Margaretha;Westerhausen, Rene;Plessen, Kerstin J.
通讯作者：
Plessen, Kerstin J.
影响因子：
4.4
作者：
Falangola, Maria F.;Jensen, Jens H.;Babb, James S.;Hu, Caixia;Castellanos, Francisco X.;Di Martino, Adriana;Ferris, Steven H.;Helpern, Joseph A.
通讯作者：
Helpern, Joseph A.