Visualising peripheral arterioles and venules through high-resolution and large-area photoacoustic imaging.
Visualising peripheral arterioles and venules through high-resolution and large-area photoacoustic imaging.
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DOI：
10.1038/s41598-018-33255-8
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发表时间：
2018-10-08
影响因子：
4.6
通讯作者：
Toi M
中科院分区：
文献类型：
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作者：
Matsumoto Y;Asao Y;Sekiguchi H;Yoshikawa A;Ishii T;Nagae KI;Kobayashi S;Tsuge I;Saito S;Takada M;Ishida Y;Kataoka M;Sakurai T;Yagi T;Kabashima K;Suzuki S;Togashi K;Shiina T;Toi M
光声成像(PAI)是一种很有前途的无创血管成像技术。先前已经报道了一种包括半球探测器阵列(HDA)的PAI系统，作为一种提供高形态重复性的方法。然而，诊断能力的进一步提高将需要改善PAI的图像质量，并融合功能成像和形态成像。我们新开发的PAI系统样机不仅提高了PA图像的分辨率，而且还可以在同一坐标轴上获取连续位置的超声(US)B型图像。此外，脉冲对脉冲交替激光照射缩短了两个波长之间的测量时间差。我们扫描了直径为140 mm的成像区域的四肢和乳房，获得了包括小动脉和小静脉在内的细小血管的3D-PA图像。我们可以利用从PA图像在两个波长上获得的S因子来估计血管是动脉还是静脉，该因子近似对应于血红蛋白的血氧饱和度。此外，我们以前所未有的分辨率观察了乳腺肿瘤周围的肿瘤相关血管。未来，我们新的PAI系统的临床研究将有助于阐明血管相关疾病和事件的各种机制。
Photoacoustic (PA) imaging (PAI) has been shown to be a promising tool for non-invasive blood vessel imaging. A PAI system comprising a hemispherical detector array (HDA) has been reported previously as a method providing high morphological reproducibility. However, further improvements in diagnostic capability will require improving the image quality of PAI and fusing functional and morphological imaging. Our newly developed PAI system prototype not only enhances the PA image resolution but also acquires ultrasonic (US) B-mode images at continuous positions in the same coordinate axes. In addition, the pulse-to-pulse alternating laser irradiation shortens the measurement time difference between two wavelengths. We scanned extremities and breasts in an imaging region 140 mm in diameter and obtained 3D-PA images of fine blood vessels, including arterioles and venules. We could estimate whether a vessel was an artery or a vein by using the S-factor obtained from the PA images at two wavelengths, which corresponds approximately to the haemoglobin oxygen saturation. Furthermore, we observed tumour-related blood vessels around breast tumours with unprecedented resolution. In the future, clinical studies with our new PAI system will help to elucidate various mechanisms of vascular-associated diseases and events.
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影响因子：
3.5
作者：
Asao, Yasufumi;Hashizume, Yohei;Toi, Masakazu
通讯作者：
Toi, Masakazu
影响因子：
4.6
作者：
Matsumoto Y;Asao Y;Yoshikawa A;Sekiguchi H;Takada M;Furu M;Saito S;Kataoka M;Abe H;Yagi T;Togashi K;Toi M
通讯作者：
Toi M
影响因子：
19.4
作者：
Dean-Ben, Xose Luis;Razansky, Daniel
通讯作者：
Razansky, Daniel
影响因子：
5.9
作者：
Heijblom, Michelle;Piras, Daniele;van den Engh, Frank M.;van der Schaaf, Margreet;Klaase, Joost M.;Steenbergen, Wiendelt;Manohar, Srirang
通讯作者：
Manohar, Srirang
影响因子：
82.9
作者：
通讯作者：
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