Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice.
Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice.
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DOI：
10.1016/j.psyneuen.2010.01.002
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发表时间：
2010-08
影响因子：
3.7
通讯作者：
Choleris, Elena
中科院分区：
文献类型：
--
作者：
Allen, Amy E. Clipperton;Cragg, Cheryl L.;Wood, Alexis J.;Pfaff, Donald W.;Choleris, Elena
关键词：
亲和性和对抗性的社会互动是由性腺激素介导的。对雌激素受体 α (ERα) 或 β (ERβ) 敲除 (KO) 小鼠的研究表明，ERα 的长期失活会减少雄性的攻击性，而 ERβ 的失活会增加雄性的攻击性。在雌性 αERKO 和 βERKO 小鼠中发现了相反的效果。 ERα 或 ERβ 的急性激活在成年非 KO 小鼠的激动反应中的作用尚不清楚。我们在此报告了 ERβ 选择性激动剂 WAY-200070 对性腺完整和性腺切除 (性腺) 的雄性和雌性 CD-1 小鼠对性腺同性入侵者的竞争和社会行为的影响。所有 15 分钟的居民-入侵者测试均被录像，以进行全面的行为分析。评估单独分析：1) WAY-200070 对每种性别和性腺状况的影响； 2) 在未经治疗的动物中，性别之间以及性腺完整和性腺小鼠之间的差异。结果表明，在性腺完整的雄性和雌性小鼠中，WAY-200070 增加了攻击行为，例如向下推和侵略性梳理毛发，同时攻击行为不受影响。在未经治疗的小鼠中，雄性比雌性更具攻击性，性腺动物比同性、性腺完整的小鼠表现出更少的攻击行为。总的来说，我们详细的行为分析表明，在性腺完整的雄性和雌性小鼠中，ERβ介导不直接参与攻击的竞争行为模式。这表明成年小鼠攻击行为的特定方面是由 ERβ 敏锐介导的。我们的结果还表明，在居民-入侵者测试中，雌性小鼠在性内竞争互动中花费的时间与雄性相同，但使用涉及极低水平直接攻击的竞争行为。雌性的这种非攻击性攻击行为会因 ERβ 的急性激活而增强。因此，ERβ 的急性激活同样介导成年雄性和雌性 CD-1 小鼠的激动行为。
Affiliative and agonistic social interactions are mediated by gonadal hormones. Research with estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice show that long-term inactivation of ERα decreases, while inactivation of ERβ increases, male aggression. Opposite effects were found in female αERKO and βERKO mice. The role of acute activation of ERα or ERβ in the agonistic responses of adult non-KO mice is unknown. We report here the effects of the ERβ selective agonist WAY-200070 on agonistic and social behavior in gonadally intact and gonadectomized (gonadex) male and female CD-1 mice towards a gonadex, same-sex intruder. All 15 min resident-intruder tests were videotaped for comprehensive behavioral analysis. Separate analyses assessed: 1) effects of WAY-200070 on each sex and gonadal condition; 2) differences between sexes, and between gonadally intact and gonadex mice, in untreated animals. Results show that in gonadally intact male and female mice WAY-200070 increased agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. In untreated mice, males attacked more than females, and gonadex animals showed less agonistic behavior than same-sex, gonadally intact mice. Overall, our detailed behavioral analysis suggested that in gonadally intact male and female mice, ERβ mediates patterns of agonistic behavior that are not directly involved in attacks. This suggests that specific aspects of aggressive behavior are acutely mediated by ERβ in adult mice. Our results also showed that, in resident-intruder tests, female mice spend as much time in intrasexual agonistic interactions as males, but use agonistic behaviors that involve extremely low levels of direct attacks. This non-attack aggression in females is increased by acute activation of ERβ. Thus, acute activation of ERβ similarly mediates agonistic behavior in adult male and female CD-1 mice.
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影响因子：
8.2
作者：
Choleris, E;Thomas, AW;Prato, FS
通讯作者：
Prato, FS
DOI：
10.1086/physzool.20.4.30151969
发表时间：
1947-01-01
期刊：
PHYSIOLOGICAL ZOOLOGY
影响因子：
--
作者：
BEEMAN, EA
通讯作者：
BEEMAN, EA
影响因子：
2.9
作者：
ANTON, AH
通讯作者：
ANTON, AH
影响因子：
3.5
作者：
CLARK, CR;NOWELL, NW
通讯作者：
NOWELL, NW
影响因子：
3.3
作者：
Curtis, JT;Wang, Z
通讯作者：
Wang, Z