Thiolene and SIFEL-based Microfluidic Platforms for Liquid-Liquid Extraction.
Thiolene and SIFEL-based Microfluidic Platforms for Liquid-Liquid Extraction.
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DOI：
10.1016/j.snb.2013.09.065
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Kenis PJ
中科院分区：
文献类型：
--
作者：
Goyal S;Desai AV;Lewis RW;Ranganathan DR;Li H;Zeng D;Reichert DE;Kenis PJ
微流体平台为液-液萃取（LLE）过程提供了优于常规方法的几个优点，例如由于固有的较短扩散距离而降低了溶剂消耗和提高了萃取效率。在这里，我们报告了基于聚合物的平行流微流体平台的LLE的发展。迄今为止，平行流微流体平台主要由硅或玻璃制成，因为它们与用于LLE的大多数有机溶剂相容。基于硅和玻璃的LLE平台的制造通常需要广泛使用光刻、基于等离子体或激光的蚀刻、高温（阳极）接合和/或用KOH或HF溶液的湿法蚀刻。相比之下，聚合物微流体平台可以使用较少涉及的工艺来制造，通常是光刻与复制模塑、热压印和/或在低得多的温度下粘合的组合。在这里，我们报告的制造和测试的微流体LLE平台组成的硫醇烯或全氟聚醚为基础的材料，SIFEL，其中材料的选择主要是由溶剂的兼容性和制造的顺从性的需要指导。使用分析建模获得了在制造方法和可行操作条件的约束内最大化提取效率的基于聚合物的LLE平台的合适设计。为了优化基于聚合物的LLE平台的性能，我们系统地研究了表面官能化和微观结构对液-液界面稳定性和相分离能力的影响。作为示范性的例子，我们报告（i）一个基于硫醇的平台，以确定咖啡因的亲脂性，和（ii）一个基于SIFEL的平台，从酸性水溶液中提取放射性铜。
Microfluidic platforms provide several advantages for liquid-liquid extraction (LLE) processes over conventional methods, for example with respect to lower consumption of solvents and enhanced extraction efficiencies due to the inherent shorter diffusional distances. Here, we report the development of polymer-based parallel-flow microfluidic platforms for LLE. To date, parallel-flow microfluidic platforms have predominantly been made out of silicon or glass due to their compatibility with most organic solvents used for LLE. Fabrication of silicon and glass-based LLE platforms typically requires extensive use of photolithography, plasma or laser-based etching, high temperature (anodic) bonding, and/or wet etching with KOH or HF solutions. In contrast, polymeric microfluidic platforms can be fabricated using less involved processes, typically photolithography in combination with replica molding, hot embossing, and/or bonding at much lower temperatures. Here we report the fabrication and testing of microfluidic LLE platforms comprised of thiolene or a perfluoropolyether-based material, SIFEL, where the choice of materials was mainly guided by the need for solvent compatibility and fabrication amenability. Suitable designs for polymer-based LLE platforms that maximize extraction efficiencies within the constraints of the fabrication methods and feasible operational conditions were obtained using analytical modeling. To optimize the performance of the polymer-based LLE platforms, we systematically studied the effect of surface functionalization and of microstructures on the stability of the liquid-liquid interface and on the ability to separate the phases. As demonstrative examples, we report (i) a thiolene-based platform to determine the lipophilicity of caffeine, and (ii) a SIFEL-based platform to extract radioactive copper from an acidic aqueous solution.
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影响因子：
7.4
作者：
Hibara, A;Nonaka, M;Kitamori, T
通讯作者：
Kitamori, T
影响因子：
6.1
作者：
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影响因子：
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Kitamori, T
影响因子：
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影响因子：
6.2
作者：
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通讯作者：
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