Influence of the geographic distribution of prion protein gene sequence variation on patterns of chronic wasting disease spread in white-tailed deer (Odocoileus virginianus).
Influence of the geographic distribution of prion protein gene sequence variation on patterns of chronic wasting disease spread in white-tailed deer (Odocoileus virginianus).
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DOI：
10.1080/19336896.2018.1474671
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发表时间：
2018
期刊：
影响因子：
2.3
通讯作者：
Mateus-Pinilla NE
中科院分区：
文献类型：
--
作者：
Brandt AL;Green ML;Ishida Y;Roca AL;Novakofski J;Mateus-Pinilla NE
管理和控制疾病在野生动物种群中的传播是具有挑战性的，特别是对于群居和流动物种。有效的管理得益于有关疾病易感性的信息，使有限的资源能够集中在感染风险较高的地区或人群。慢性消耗性疾病(CWD)是一种影响宫颈的传染性海绵状脑病，于20世纪60年代末在科罗拉多州被发现。CWD于2002年在伊利诺伊州和威斯康星州被发现，此后已蔓延到许多县。Prion蛋白基因(PRNP)序列中的特定核苷酸变异与白尾鹿CWD易感性降低有关。尽管遗传抗性是不完全的，但鹿在种群中拥有这些突变的频率是疾病传播(即群体免疫)的一个重要因素。在本研究中，我们对来自伊利诺伊州和威斯康星州的2433头鹿的PRNP基因进行了625个碱基的测序。在伊利诺伊州中北部首次发现CWD的县，保护性单倍型的频率较低(频率为0.20)；而在伊利诺伊州西北部的县，那里最近才发现CWD病例，保护性单倍型的频率(频率为0.30)要高得多(P<0.05)。保护性单倍型频率在感染和未感染的地理区域之间存在显著差异。保护性PRNP单倍型的频率可能有助于人群水平的易感性，并可能塑造CWD在伊利诺伊州传播的方式。对PRNP单倍型分布的分析可能是评估CWD风险和分配资源以控制和减少感染传播的有用工具。
Managing and controlling the spread of diseases in wild animal populations is challenging, especially for social and mobile species. Effective management benefits from information about disease susceptibility, allowing limited resources to be focused on areas or populations with a higher risk of infection. Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that affects cervids, was detected in Colorado in the late 1960s. CWD was detected in Illinois and Wisconsin in 2002 and has since spread through many counties. Specific nucleotide variations in the prion protein gene (PRNP) sequence have been associated with reduced susceptibility to CWD in white-tailed deer. Though genetic resistance is incomplete, the frequency of deer possessing these mutations in a population is an important factor in disease spread (i.e. herd immunity). In this study we sequenced 625 bp of the PRNP gene from a sampling of 2433 deer from Illinois and Wisconsin. In north-central Illinois where CWD was first detected, counties had a low frequency of protective haplotypes (frequency <0.20); whereas in northwestern Illinois counties, where CWD cases have only more recently been detected, the frequency of protective haplotypes (frequency >0.30) was much higher (p < 0.05). Protective haplotype frequencies varied significantly among infected and uninfected geographic areas. The frequency of protective PRNP haplotypes may contribute to population level susceptibility and may shape the way CWD has spread through Illinois. Analysis of PRNP haplotype distribution could be a useful tool to assess CWD risk and allocate resources to contain and reduce the spread of infection.
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影响因子：
1.7
作者：
Green, Michelle L.;Manjerovic, Mary Beth;Novakofski, Jan
通讯作者：
Novakofski, Jan
影响因子：
3.3
作者：
Blanchong, Julie A.;Samuel, Michael D.;Filcek, Kristine B.
通讯作者：
Filcek, Kristine B.
影响因子：
4.6
作者：
Dorak, Sheena J.;Green, Michelle L.;Mateus-Pinilla, Nohra E.
通讯作者：
Mateus-Pinilla, Nohra E.
影响因子：
2.3
作者：
Gross, JE;Miller, MW
通讯作者：
Miller, MW
影响因子：
4.1
作者：
Cullingham, Catherine I.;Merrill, Evelyn H.;Coltman, David W.
通讯作者：
Coltman, David W.