Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women.
Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women.
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DOI：
10.3390/life13020408
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发表时间：
2023-02-01
期刊：
影响因子：
3.2
通讯作者：
Fujino, Hidemi
中科院分区：
文献类型：
--
作者：
Nisa, Badur Un;Nakanishi, Ryosuke;Tanaka, Minoru;Lin, Hao;Hirabayashi, Takumi;Maeshige, Noriaki;Kondo, Hiroyo;Fujino, Hidemi
关键词：
轻度高压氧（HBO）增强血液中的氧气吸收，缓解疲劳而不引起氧化应激。轻度高压氧在治疗生活方式相关疾病和高血压方面的益处已得到认可，但尚未对其对免疫的影响进行研究。本研究的目的是探讨轻度HBO对健康年轻女性自然杀伤（NK）细胞和细胞因子的影响。这项交叉随机对照试验在16名健康年轻女性中进行。参与者在高压氧舱中随机暴露于常压氧（NBO； 1.0大气压（ATA）， 20.8%氧气）和轻度高压氧条件（1.4大气压，35-40%氧气，每分钟注射18L氧气）70分钟。在两种暴露前后分别测量心率、副交感神经活动、NK细胞计数、白细胞介素(IL)-6、IL-12p70和活性氧代谢物衍生物（d-ROMs）。在NBO条件下，副交感神经活动保持不变，而轻度HBO暴露后，副交感神经活动显著增加。NBO暴露后NK细胞保持不变，而轻度HBO暴露后NK细胞增加。暴露于轻度HBO没有增加- rom值、IL-6和IL-12p70蛋白水平。这些发现表明，暴露于轻度HBO可以通过增加氧气输送来调节副交感神经活动，从而增加NK细胞。
Mild hyperbaric oxygen (HBO) enhances oxygen absorption in blood, relieving fatigue without causing oxidative stress. The benefits of mild HBO have been recognized in the treatment of lifestyle-related diseases and hypertension, but no research has been conducted on its effects on immunity. The aim of the present study is to investigate the effect of mild HBO on natural killer (NK) cells and cytokines in healthy young women. This crossover randomized control trial was conducted with 16 healthy young women. Participants were randomly exposed to normobaric oxygen (NBO; 1.0 atmospheres absolute (ATA), 20.8% oxygen) and mild HBO conditions (1.4 ATA, 35–40% oxygen, injected 18L oxygen per minute) in a hyperbaric oxygen chamber for 70 min. Heart rate, parasympathetic activity, NK cell count, interleukin (IL)-6, IL-12p70 and derivatives of reactive oxygen metabolites (d-ROMs) were measured before and after both exposures. In the NBO condition, parasympathetic activity remained unchanged, whereas after mild HBO exposure, parasympathetic activity was significantly increased. NK cells remained unchanged after NBO exposure, while NK cells were increased after exposure to mild HBO. Exposure to mild HBO did not increase d-ROM values, IL-6 and IL-12p70 protein levels. These findings suggest that exposure to mild HBO can be a useful protocol to increase NK cells by regulating parasympathetic activity via increasing oxygen delivery.
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影响因子：
4
作者：
de Wolde SD;Hulskes RH;de Jonge SW;Hollmann MW;van Hulst RA;Weenink RP;Kox M
通讯作者：
Kox M
影响因子：
3.1
作者：
Heitkemper, M;Burr, RL;Bond, EF
通讯作者：
Bond, EF
影响因子：
--
作者：
Krog, Jan;Tonnesen, Else K.;Hokland, Marianne E.
通讯作者：
Hokland, Marianne E.
影响因子：
2.9
作者：
Hehenberger, Karin;Brismar, Kerstin;Kratz, Gunnar
通讯作者：
Kratz, Gunnar
影响因子：
3.8
作者：
Hartmann, G;Tschöp, M;Toepfer, M
通讯作者：
Toepfer, M