Precision manufacture of phase-change perfluorocarbon droplets using microfluidics.
Precision manufacture of phase-change perfluorocarbon droplets using microfluidics.
复制标题
DOI：
10.1016/j.ultrasmedbio.2011.08.012
复制
发表时间：
2011-11
影响因子：
2.9
通讯作者：
Dayton, Paul A.
中科院分区：
文献类型：
--
作者：
Martz, Thomas D.;Sheeran, Paul S.;Bardin, David;Lee, Abraham P.;Dayton, Paul A.
液态全氟化碳液滴在医学声学界一直受到关注，用作组织闭塞、成像和治疗的声激活颗粒。迄今为止，生产液体全氟化碳液滴的方法通常导致多分散的尺寸分布。由于声激活的阈值是直径的函数，因此单分散群体将有利于保持声激活参数的均匀性。通过使用具有流动聚焦技术的微流体装置，证明了具有均匀尺寸分布的全氟戊烷液滴的产生。稳定性研究表明，这些液滴在储存中至少稳定两周。声学研究说明了作为液滴直径的函数的蒸发阈值，并且在所研究的尺寸范围内观察到声压与蒸发阈值之间的对数关系。均匀尺寸的液滴在声蒸发阈值上具有非常小的变化。结果表明，微流控技术可以使更大的相变全氟化碳的声学液滴蒸发应用的制造控制。
Liquid perfluorocarbon droplets have been of interest in the medical acoustics community for use as acoustically activated particles for tissue occlusion, imaging, and therapeutics. To date, methods to produce liquid perfluorocarbon droplets typically result in a polydisperse size distribution. Since the threshold of acoustic activation is a function of diameter, there would be benefit from a monodisperse population to preserve uniformity in acoustic activation parameters. Through the use of a microfluidic device with flow focusing technology, the production of droplets of perfluoropentane with a uniform size distribution is demonstrated. Stability studies indicate that these droplets are stable in storage for at least two weeks. Acoustic studies illustrate the thresholds of vaporization as a function of droplet diameter, and a logarithmic relationship is observed between acoustic pressure and vaporization threshold within the size ranges studied. Droplets of uniform size have very little variability in acoustic vaporization threshold. Results indicate that microfluidic technology can enable greater manufacturing control of phase change perfluorocarbons for acoustic droplet vaporization applications.
登录
查看更多内容
影响因子：
2.9
作者：
Zhang, M.;Fabiilli, M. L.;Haworth, K. J.;Fowlkes, J. B.;Kripfgans, O. D.;Roberts, W. W.;Ives, K. A.;Carson, P. L.
通讯作者：
Carson, P. L.
影响因子：
4.8
作者：
Zhang, Man;Fabiilli, Mario L.;Haworth, Kevin J.;Padilla, Frederic;Swanson, Scott D.;Kripfgans, Oliver D.;Carson, Paul L.;Fowlkes, Jeffrey Brian
通讯作者：
Fowlkes, Jeffrey Brian
影响因子：
3.7
作者：
Fabiilli, Mario L.;Lee, James A.;Kripfgans, Oliver D.;Carson, Paul L.;Fowlkes, J. Brian
通讯作者：
Fowlkes, J. Brian
DOI：
10.1109/tuffc.2005.1503996
发表时间：
2005-07-01
影响因子：
3.6
作者：
Kripfgans, OD;Orifici, CM;Fowlkes, JB
通讯作者：
Fowlkes, JB
DOI：
10.1109/tuffc.2002.1009331
发表时间：
2002-06-01
影响因子：
3.6
作者：
Kripfgans, OD;Fowlkes, JB;Carson, PL
通讯作者：
Carson, PL