Fish zona radiata (eggshell) protein: a sensitive biomarker for environmental estrogens.

Fish zona radiata (eggshell) protein: a sensitive biomarker for environmental estrogens.
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DOI:
10.1289/ehp.97105418
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发表时间:
1997-04
影响因子:
10.4
通讯作者:
Goksøyr A
Goksøyr A
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Arukwe A;Knudsen FR;Goksøyr A

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环境雌激素由于具有模仿天然激素的能力,影响人类和野生动物重要的内分泌功能,近年来引起了人们的极大关注。环境雌激素对胎生脊椎动物卵黄蛋白原(Vtg)合成的诱导作用已被认为是一种有效而敏感的雌激素样生物标志物。大西洋鲑鱼(萨尔莫salar)暴露于4-壬基酚(NP)或从炼油厂污水处理厂(OLTP)的血浆的免疫化学分析表明,NP和OLTP污水诱导Vtg和辐射蛋白(Zrp)的剂量依赖性的方式。然而,Zrp-β交叉反应蛋白比Zrp-α、Zrp-γ和Vtg更敏感。Zrp诱导的敏感性指向作为雌激素活性的替代生物标志物的辐射蛋白。
Environmental estrogens have recently caused great concern because of their ability to mimic natural hormones and influence vital endocrine functions in humans and wildlife. The induction of vitellogenin (Vtg) synthesis by environmental estrogens in viviparous vertebrates has been proposed as an effective and sensitive biomarker of estrogenicity. Immunochemical analysis of plasma from Atlantic salmon (Salmo salar) exposed to 4-nonylphenol (NP) or to effluent from oil refinery treatment plant (ORTP), shows that NP and ORTP effluent induces Vtg and zona radiata proteins (Zrp) in a dose-dependent manner. However, Zrp-beta cross-reactive proteins are more responsive than Zrp-alpha, Zrp-gamma, and Vtg. The sensitivity of Zrp induction points to the zona radiata proteins as alternate biomarkers of estrogenicity.
DOI: 10.1289/ehp.96104s4715
发表时间: 1996-08
影响因子: 10.4
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Kavlock RJ;Daston GP;DeRosa C;Fenner-Crisp P;Gray LE;Kaattari S;Lucier G;Luster M;Mac MJ;Maczka C;Miller R;Moore J;Rolland R;Scott G;Sheehan DM;Sinks T;Tilson HA
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