Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).
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DOI：
10.1016/j.yfrne.2008.11.002
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发表时间：
2009-01
影响因子：
7.4
通讯作者：
Mellon, Synthia H.
中科院分区：
文献类型：
--
作者：
Maninger, Nicole;Wolkowitz, Owen M.;Reus, Victor I.;Epel, Elissa S.;Mellon, Synthia H.
关键词：
脱氢表雄酮（DHEA）和脱氢表雄酮（DHEAS）是人类肾上腺合成的类固醇，但其功能尚不清楚。除了肾上腺合成外，有证据表明DHEA和DHEAS也在大脑中合成，进一步表明这些激素在大脑功能和发育中的作用。尽管对脱氢表雄酮和脱氢表雄酮的生物学研究越来越深入，但关于它们的作用机制和它们在神经精神疾病中的潜在参与的许多问题仍未得到解答。我们回顾并提炼了DHEA和DHEAS的临床前和临床数据，重点关注(i)生物作用和可能的作用机制，（ii）正常受试者和神经精神疾病患者内源性循环浓度的差异，以及（iii） DHEA在治疗这些疾病中的治疗潜力。脱氢表雄酮和脱氢表雄酮的生物学作用包括神经保护、神经突生长和对氧化剂和糖皮质激素的拮抗作用。越来越多的数据表明DHEA和/或DHEAS浓度在几种神经精神疾病中异常。综述了DHEA和DHEAS在某些情况下可能成为药物治疗的有效靶点的证据。
DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are synthesized in the brain, further suggesting a role of these hormones in brain function and development. Despite intensifying research into the biology of DHEA and DHEAS, many questions concerning their mechanisms of action and their potential involvement in neuropsychiatric illnesses remain unanswered. We review and distill the preclinical and clinical data on DHEA and DHEAS, focusing on (i) biological actions and putative mechanisms of action, (ii) differences in endogenous circulating concentrations in normal subjects and patients with neuropsychiatric diseases, and (iii) the therapeutic potential of DHEA in treating these conditions. Biological actions of DHEA and DHEAS include neuroprotection, neurite growth, and antagonistic effects on oxidants and glucocorticoids. Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed.
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DOI：
10.1016/j.beem.2004.02.006
发表时间：
2004-09-01
影响因子：
7.4
作者：
Arlt, W
通讯作者：
Arlt, W
DOI：
10.1111/j.1532-5415.1998.tb01036.x
发表时间：
1998-03-01
影响因子：
6.3
作者：
Abbasi, A;Duthie, EH;Mattson, DE
通讯作者：
Mattson, DE
DHEA 给药对健康年轻男性情景记忆、皮质醇和情绪的影响：一项双盲、安慰剂对照研究
影响因子：
3.4
作者：
Alhaj, Hamid A.;Massey, Anna E.;McAllister-Williams, R. Hamish
通讯作者：
McAllister-Williams, R. Hamish
影响因子：
3.7
作者：
Armanini, D;Vecchio, F;Karbowiak, I
通讯作者：
Karbowiak, I
影响因子：
3.8
作者：
Aldred, S;Waring, RH
通讯作者：
Waring, RH