Balanced trade-offs between alternative strategies shape the response of C. elegans reproduction to chronic heat stress.
Balanced trade-offs between alternative strategies shape the response of C. elegans reproduction to chronic heat stress.
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DOI：
10.1371/journal.pone.0105513
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ruvinsky I
中科院分区：
文献类型：
--
作者：
Aprison EZ;Ruvinsky I
为了确保长期繁殖成功，生物体必须科普恶劣的极端环境。简单地最大化后代产量的繁殖策略可能是不利的，因为它可能导致在不利条件下繁殖力的灾难性损失。为了了解如何实现适当的平衡，我们调查了C。elegans在慢性热应激的条件下。我们发现，即使长时间暴露在没有后代存活的温度下，蠕虫也可以恢复并恢复繁殖。在暴露于高于28°C的温度后，产生存活后代的可能性福尔斯急剧下降，主要是由于精子受损。令人惊讶的是，我们发现，经历了较高温度的蠕虫可以恢复得更好，只要它们没有开始排卵。因此，控制这一过程的机制必须在确定恢复的可能性方面发挥至关重要的作用。然而，我们发现，抑制排卵只有在相对较长的压力下才是有益的，而在相同强度的较短压力下，这是一种不利的策略。这是因为停止产卵从而保护生殖系统的好处被实施这一策略的相关成本所抵消-恢复和产生后代需要相当长的时间。我们将这些平衡的权衡解释为C。线虫的生殖系统对压力的反应和对多变和不可预测条件下生活的适应。
To ensure long-term reproductive success organisms have to cope with harsh environmental extremes. A reproductive strategy that simply maximizes offspring production is likely to be disadvantageous because it could lead to a catastrophic loss of fecundity under unfavorable conditions. To understand how an appropriate balance is achieved, we investigated reproductive performance of C. elegans under conditions of chronic heat stress. We found that following even prolonged exposure to temperatures at which none of the offspring survive, worms could recover and resume reproduction. The likelihood of producing viable offspring falls precipitously after exposure to temperatures greater than 28°C primarily due to sperm damage. Surprisingly, we found that worms that experienced higher temperatures can recover considerably better, provided they did not initiate ovulation. Therefore mechanisms controlling this process must play a crucial role in determining the probability of recovery. We show, however, that suppressing ovulation is only beneficial under relatively long stresses, whereas it is a disadvantageous strategy under shorter stresses of the same intensity. This is because the benefit of shutting down egg laying, and thus protecting the reproductive system, is negated by the cost associated with implementing this strategy – it takes considerable time to recover and produce offspring. We interpret these balanced trade-offs as a dynamic response of the C. elegans reproductive system to stress and an adaptation to life in variable and unpredictable conditions.
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影响因子：
30.8
作者：
Andersen, Erik C.;Gerke, Justin P.;Shapiro, Joshua A.;Crissman, Jonathan R.;Ghosh, Rajarshi;Bloom, Joshua S.;Felix, Marie-Anne;Kruglyak, Leonid
通讯作者：
Kruglyak, Leonid
DOI：
10.1534/g3.112.005165
发表时间：
2013-04-09
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Bilgir C;Dombecki CR;Chen PF;Villeneuve AM;Nabeshima K
通讯作者：
Nabeshima K
影响因子：
56.9
作者：
Arantes-Oliveira, N;Apfeld, J;Kenyon, C
通讯作者：
Kenyon, C
影响因子：
2.7
作者：
Feder, ME
通讯作者：
Feder, ME
影响因子：
3.3
作者：
Bui, YK;Sternberg, PW
通讯作者：
Sternberg, PW