In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors.
In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors.
复制标题
DOI：
10.1002/jbm.a.31824
复制
发表时间：
2008-12-01
影响因子：
4.9
通讯作者：
Reichert, W. M.
中科院分区：
文献类型：
--
作者：
Koschwanez, H. E.;Yap, F. Y.;Klitzman, B.;Reichert, W. M.
本研究的目的是验证多孔聚乳酸（PLLA）传感器涂层减少纤维化并促进传感器表面附近组织中血液微血管形成的假设。使用碳酸氢铵作为气体发泡/盐浸出剂制备多孔PLLA涂层，并将其部署在功能性和非功能性传感器上。多孔涂层对传感器精度和响应率的影响最小。对无功能葡萄糖传感器进行的为期三周的大鼠皮下研究显示，多孔涂层可增强血管性，减少胶原沉积。相比之下，有和没有多孔涂层的经皮功能传感器在组织学或传感器反应方面没有显着差异。尽管观察到纹理增加了植入传感器周围组织的血管性，但其他因素，如经皮系带施加的额外机械应力，可能会覆盖多孔涂层的有益效果。
The purpose of this study was to test the hypothesis that porous poly-l-lactic acid (PLLA) sensor coatings reduce fibrosis and promote blood microvessel formation in tissue adjacent to the sensor surface. Porous PLLA coatings were produced using ammonium bicarbonate as the gas foaming/salt leaching agent, and deployed on functional and nonfunctional sensors. The porous coatings minimally affected sensor accuracy and response rate in vitro. Three-week subcutaneous rat studies of nonfunctional glucose sensors showed the anticipated effect of porous coatings enhancing vascularity and decreasing collagen deposition. In contrast, percutaneous functional sensors with and without porous coatings showed no significant difference in terms of histology or sensor response. In spite of the observation that texturing increases the vascularity of the tissue that surrounds implanted sensors, other factors such as the additional mechanical stresses imposed by percutaneous tethering may override the beneficial effects of the porous coatings.
登录
查看更多内容
影响因子：
14
作者：
Norton, LW;Tegnell, E;Reichert, WM
通讯作者：
Reichert, WM
影响因子：
2.4
作者：
Tagusari, O;Yamazaki, K;Kormos, RL
通讯作者：
Kormos, RL
影响因子：
3
作者：
Maynard, EM;Fernandez, E;Normann, RA
通讯作者：
Normann, RA
影响因子：
5.4
作者：
Long, Nathan;Yu, Bazhang;Moussy, Francis
通讯作者：
Moussy, Francis
影响因子：
14
作者：
Ramay, HR;Zhang, MQ
通讯作者：
Zhang, MQ