Influence of Pre-Training Predator Stress on the Expression of c-fos mRNA in the Hippocampus, Amygdala, and Striatum Following Long-Term Spatial Memory Retrieval.
Influence of Pre-Training Predator Stress on the Expression of c-fos mRNA in the Hippocampus, Amygdala, and Striatum Following Long-Term Spatial Memory Retrieval.
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DOI：
10.3389/fnbeh.2011.00030
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发表时间：
2011
影响因子：
3
通讯作者：
Diamond DM
中科院分区：
文献类型：
--
作者：
Vanelzakker MB;Zoladz PR;Thompson VM;Park CR;Halonen JD;Spencer RL;Diamond DM
本实验研究了训练前心理应激对长时空间记忆提取后c-fos mRNA表达的影响。训练大鼠在桡臂水迷宫中学习隐藏的逃避平台的位置，然后在24 h后评估其对平台位置的记忆。在24小时记忆测试试验后30分钟提取大鼠脑用于分析c-fos mRNA。测试了四组：（1）给予标准训练的大鼠（标准）;（2）在训练前30分钟给予猫暴露（捕食者应激）的大鼠（训练前应激）;（3）仅给予水暴露的大鼠（水应激）;和（4）不给予水暴露的大鼠（家笼）。标准训练组表现出良好的24 h记忆，并伴有背侧海马和基底外侧杏仁核（BLA）中c-fos mRNA的增加。水煎药组各脑区c-fos mRNA均无明显增加。训练前应激组大鼠分为记忆力好和记忆力差两个亚组。两个训练前应激亚组的背侧海马或BLA中c-fos mRNA表达均未表现出显著变化。相反，与记忆力差的应激大鼠相比，记忆力好的应激大鼠背外侧纹状体（DLS）的c-fos mRNA表达显著增加。这一发现表明，具有良好记忆力的应激大鼠使用其DLS产生非空间（基于线索）策略来学习并随后检索平台位置的记忆。总的来说，这些研究结果提供了证据，在分子水平上参与的海马和BLA在检索的空间记忆和贡献的影响，训练前的压力在激活DLS响应于长期记忆检索的新的观察。
We have studied the influence of pre-training psychological stress on the expression of c-fos mRNA following long-term spatial memory retrieval. Rats were trained to learn the location of a hidden escape platform in the radial-arm water maze, and then their memory for the platform location was assessed 24 h later. Rat brains were extracted 30 min after the 24-h memory test trial for analysis of c-fos mRNA. Four groups were tested: (1) Rats given standard training (Standard); (2) Rats given cat exposure (Predator Stress) 30 min prior to training (Pre-Training Stress); (3) Rats given water exposure only (Water Yoked); and (4) Rats given no water exposure (Home Cage). The Standard trained group exhibited excellent 24 h memory which was accompanied by increased c-fos mRNA in the dorsal hippocampus and basolateral amygdala (BLA). The Water Yoked group exhibited no increase in c-fos mRNA in any brain region. Rats in the Pre-Training Stress group were classified into two subgroups: good and bad memory performers. Neither of the two Pre-Training Stress subgroups exhibited a significant change in c-fos mRNA expression in the dorsal hippocampus or BLA. Instead, stressed rats with good memory exhibited significantly greater c-fos mRNA expression in the dorsolateral striatum (DLS) compared to stressed rats with bad memory. This finding suggests that stressed rats with good memory used their DLS to generate a non-spatial (cue-based) strategy to learn and subsequently retrieve the memory of the platform location. Collectively, these findings provide evidence at a molecular level for the involvement of the hippocampus and BLA in the retrieval of spatial memory and contribute novel observations on the influence of pre-training stress in activating the DLS in response to long-term memory retrieval.
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