Peripubertal blood lead levels and growth among Russian boys.
Peripubertal blood lead levels and growth among Russian boys.
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DOI：
10.1016/j.envint.2017.05.023
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发表时间：
2017-09
影响因子：
11.8
通讯作者：
Korrick SA
中科院分区：
文献类型：
--
作者：
Burns JS;Williams PL;Lee MM;Revich B;Sergeyev O;Hauser R;Korrick SA
儿童血铅水平（BLL）与生长障碍有关。我们在一个纵向队列的俄罗斯男孩中评估了青春期前后BLL与青春期生长和接近成年身高的关系。481名男孩在8-9岁时入组，每年随访一次，直到18岁。在入组时，测量BLL，并在10年随访期间每年获得身高、体重和青春期分期。混合效应模型用于评估BLL与纵向年龄调整的世界卫生组织身高Z评分（HT-Z）和体重指数（BMI-Z）以及年身高增长速度（HV）的相关性。男孩的年龄和BLL对生长结果的相互作用进行了评估。中位（范围）BLL为3.0（0.5-31.0）μg/dL。在18岁时，79%的男孩达到了接近成人的身高（HV <1.0 cm/年），HT-Z和BMI-Z的平均值（SD）分别为0.15（0.92）和-0.32（1.24）。在10年的随访中，协变量调整后，BLL较高（≥ 5 μg/dL）的男孩与BLL较低的男孩相比身高较短（HT-Z的调整后平均差异= −0.43，95% CI −0.60，−0.25，p值<0.001），转换为18岁时身高较低2.5 cm。具有较高BLL的男孩的身高下降在12至15岁时最明显（交互作用p=0.03）。BLL较高的男孩更瘦（BMI-Z的校正平均差异=-0.22，95% CI：-0.45，0.01，p=0.06）。较高的青春期BLL与18岁以下的较短身高相关，表明铅对线性生长的持续影响。
Childhood blood lead levels (BLL) have been associated with growth impairment. We assessed associations of peripubertal BLL with adolescent growth and near adult height in a longitudinal cohort of Russian boys. 481 boys were enrolled at ages 8–9 years and followed annually to age 18. At enrollment, BLL was measured, and height, weight, and pubertal staging were obtained annually during 10 years of follow-up. Mixed effects models were used to assess the associations of BLL with longitudinal age-adjusted World Health Organization Z-scores for height (HT-Z) and body mass index (BMI-Z), and annual height velocity (HV). Interactions between boys’ age and BLL on growth outcomes were evaluated. The median (range) BLL was 3.0 (0.5–31.0) μg/dL. At age 18 years, 79% of boys had achieved near adult height (HV <1.0 cm/year), and means (SD) for HT-Z and BMI-Z were 0.15 (0.92) and −0.32 (1.24). Over 10 years of follow-up, after covariate adjustment, boys with higher (≥ 5 μg/dL) BLL compared with lower BLL were shorter (adjusted mean difference in HT-Z = −0.43, 95% CI −0.60, −0.25, p-value <0.001), translating to a 2.5 cm lower height at age 18 years. The decrement in height for boys with higher BLL was most pronounced at 12 to 15 years of age (interaction p=0.03). Boys with higher BLL were leaner (adjusted mean difference in BMI-Z = −0.22, 95% CI: −0.45, 0.01, p=0.06). Higher peripubertal BLLs were associated with shorter height through age 18 years, suggesting a persistent effect of lead on linear growth.
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影响因子：
10.4
作者：
Burns JS;Lee MM;Williams PL;Korrick SA;Sergeyev O;Lam T;Revich B;Hauser R
通讯作者：
Hauser R
影响因子：
5.1
作者：
Afeiche, Myriam;Peterson, Karen E.;Tellez-Rojo, Martha M.
通讯作者：
Tellez-Rojo, Martha M.
影响因子：
1.7
作者：
Little, B. B.;Spalding, S.;Gratton, T.
通讯作者：
Gratton, T.
两岁墨西哥儿童中铅与锌状况的差异关联。
DOI：
10.1186/s12940-015-0086-8
发表时间：
2015-12-30
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Cantoral A;Téllez-Rojo MM;Levy TS;Hernández-Ávila M;Schnaas L;Hu H;Peterson KE;Ettinger AS
通讯作者：
Ettinger AS
与子宫内暴露于多环芳烃（PAH）和重金属相关的儿童的降低高度增长：同胞前瞻性研究。
影响因子：
8.3
作者：
Jedrychowski, Wieslaw A.;Perera, Frederica P.;Majewska, Renata;Mrozek-Budzyn, Dorota;Mroz, Elzbieta;Roen, Emily L.;Sowa, Agata;Jacek, Ryszard
通讯作者：
Jacek, Ryszard