Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor.
Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor.
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DOI：
10.1186/s12885-016-2926-5
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发表时间：
2016-11-18
期刊：
影响因子：
3.8
通讯作者：
Homma Y
中科院分区：
文献类型：
--
作者：
Yamada Y;Nakagawa T;Sugihara T;Horiuchi T;Yoshizaki U;Fujimura T;Fukuhara H;Urano T;Takayama K;Inoue S;Kume H;Homma Y
免疫细胞在睾丸生殖细胞肿瘤（TGCT）中的预后价值尚不清楚。我们的目的是研究肿瘤浸润性中性粒细胞在TGCT中的预后价值。对102例因TGCT行睾丸切除术的患者进行了CD 66 b阳性肿瘤浸润中性粒细胞（CD 66 b + TIN）的研究。如所述，在102个切片中进行CD 66 b的免疫染色。评估临床病理学参数以及癌症特异性生存和总生存与CD 66 b + TIN密度的相关性。高密度组与肿瘤直径≥ 10 cm、有无淋巴结/远处转移、S分期、非恶性生殖细胞肿瘤（NGCT）诊断和有无静脉浸润显著相关（分别为p = 0.0198、p < 0.0001、p = 0.0275、p = 0.0004和p = 0.0287）。它还与癌症特异性和总生存率显著相关（分别为logrank p = 0.0036和p = 0.0002）。多因素分析显示，CD 66 b + TIN增加是总生存率的独立预后因素（p = 0.0095）。CD 66 b + TIN增加与转移、S期和非恶性生殖细胞肿瘤诊断显著相关。它也是TGCT患者总生存期的独立预后因素。本文的在线版本（doi：10.1186/s12885-016-2926-5）包含补充材料，可供授权用户使用。
Prognostic value of immune cells is not clear in testicular germ cell tumors (TGCTs). We aimed to investigate the prognostic value of tumor-infiltrating neutrophils in TGCTs. A total of 102 patients who underwent orchiectomy for TGCT were investigated for CD66b positive tumor-infiltrating neutrophils (CD66b + TINs). Immmunostaining for CD66b was performed in 102 sections as described. Clinicopathological parameters as well as cancer specific survival and overall survival were assessed for correlation with CD66b + TIN density. High density group was significantly correlated with tumor diameter ≥ 10 cm, presence of nodal/distant metastasis, S stage, diagnosis of nonseminomatous germ cell tumor (NGCT), and presence of venous invasion (p = 0.0198, p < 0.0001, p = 0.0275, p = 0.0004, and p = 0.0287, respectively). It was also significantly associated with cancer-specific and overall survival (logrank p = 0.0036, and p = 0.0002, respectively). Multivariate analysis showed that increased CD66b + TIN was an independent prognostic factor for overall survival (p = 0.0095). Increased CD66b + TIN was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. It was also an independent prognostic factor of overall survival in patients with TGCT. The online version of this article (doi:10.1186/s12885-016-2926-5) contains supplementary material, which is available to authorized users.
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影响因子：
1.4
作者：
Yamada Y;Fujimura T;Takahashi S;Takayama K;Urano T;Murata T;Obinata D;Ouchi Y;Homma Y;Inoue S
通讯作者：
Inoue S
结直肠癌瘤内中性粒细胞增多与恶性表型密切相关，可预测患者的不良预后。
影响因子：
3.7
作者：
Rao HL;Chen JW;Li M;Xiao YB;Fu J;Zeng YX;Cai MY;Xie D
通讯作者：
Xie D
与肿瘤相关的CD66B+中性粒细胞计数是局部宫颈癌复发的独立预后因素。
影响因子：
8.8
作者：
Carus A;Ladekarl M;Hager H;Nedergaard BS;Donskov F
通讯作者：
Donskov F
影响因子：
45.3
作者：
Jensen, Hanne Krogh;Donskov, Frede;von der Maase, Hans
通讯作者：
von der Maase, Hans
影响因子：
3
作者：
Dutta, Sumanta;Crumley, Andrew B. C.;McMillan, Donald C.
通讯作者：
McMillan, Donald C.