Effects of Particulate Matter on the Risk of Gestational Hypertensive Disorders and Their Progression.
Effects of Particulate Matter on the Risk of Gestational Hypertensive Disorders and Their Progression.
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颗粒物对妊娠高血压疾病风险及其进展的影响。
DOI：
10.1021/acs.est.2c06573
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发表时间：
2023-03-28
影响因子：
11.4
通讯作者：
Wu, Yan-Ting
中科院分区：
文献类型：
--
作者：
Li, Cheng;Xu, Jing-Jing;Zhou, Fang-Yue;Qin, Kai-Zhou;Ge, Ying-Zhou;Huang, He-Feng;Wu, Yan-Ting
关键词：
颗粒物（PM）和妊娠期高血压疾病（GHD）之间的关联已被充分记录，但没有证据表明PM和GHD进展之间的关联，特别是在辅助生殖技术（ART）概念中。为了探讨PM对自然受孕或ART受孕孕妇GHD风险及其进展的影响，我们在2014-2020年期间在上海招募了185，140名孕妇，并使用多变量logistic回归估计了不同时期的相关性。在孕前3个月内，PM浓度增加10 μg/m3与妊娠期高血压（GH）风险增加相关。（PM2.5：aOR = 1.076，95%CI：1.034-1.120; PM10：aOR = 1.042，95%CI：1.006-1.079）和先兆子痫（PM2.5：aOR = 1.064，95%CI：1.008-1.122; PM10：aOR = 1.048，95%CI：1.006-1.092）。此外，对于目前患有GHD的ART概念的女性，晚期妊娠PM浓度增加10 μg/m3会增加进展风险（PM2.5：aOR = 1.156，95% CI：1.022-1.306 ; PM10：aOR = 1.134，95% CI：1.013-1.270）。总之，自然受孕的妇女应避免孕前PM暴露，以保护自己免受GH和先兆子痫的影响。对于患有GHD的ART概念的女性，有必要避免妊娠后期的PM暴露，以防止疾病进展。在自然受孕的妇女中，孕前PM暴露与妊娠期高血压和先兆子痫相关。对于患有妊娠期高血压疾病的女性，辅助生殖技术，妊娠后期PM暴露与进展相关。
Associations between particulate matter (PM) and gestational hypertensive disorders (GHDs) are well documented, but there is no evidence on the associations between PM and GHD progression, especially among those with assisted reproductive technology (ART) conceptions. To explore the effects of PM on the risk of GHDs and their progression among pregnant women with natural or ART conception, we enrolled 185,140 pregnant women during 2014–2020 in Shanghai and estimated the associations during different periods using multivariate logistic regression. During the 3 months of preconception, 10 μg/m3 increases in PM concentrations were associated with increased risks of gestational hypertension (GH) (PM2.5: aOR = 1.076, 95% CI: 1.034–1.120; PM10: aOR = 1.042, 95% CI: 1.006–1.079) and preeclampsia (PM2.5: aOR = 1.064, 95% CI: 1.008–1.122; PM10: aOR = 1.048, 95% CI: 1.006–1.092 ) among women with natural conception. Furthermore, for women with ART conceptions who suffered current GHD, 10 μg/m3 increases in PM concentrations in the third trimester elevated the risk of progression (PM2.5: aOR = 1.156, 95% CI: 1.022–1.306 ; PM10: aOR = 1.134, 95% CI: 1.013–1.270). In summary, women with natural conception should avoid preconceptional PM exposure to protect themselves from GH and preeclampsia. For women with ART conceptions suffering from GHD, it is necessary to avoid PM exposure in late pregnancy to prevent the disease from progressing. Preconceptional PM exposures were associated with gestational hypertension and preeclampsia among women with natural conception. For women suffering from gestational hypertensive disorders who conceived with assisted reproductive technology, PM exposures in late pregnancy were associated with progression.
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影响因子：
4.5
作者：
Jia L;Liu Q;Hou H;Guo G;Zhang T;Fan S;Wang L
通讯作者：
Wang L
影响因子：
3.1
作者：
Kenigsberg, Shlomit;Bentov, Yaakov
通讯作者：
Bentov, Yaakov
影响因子：
2.3
作者：
Lee PC;Roberts JM;Catov JM;Talbott EO;Ritz B
通讯作者：
Ritz B
DOI：
10.1016/j.scitotenv.2018.09.362
发表时间：
2019-02-10
期刊：
The Science of the total environment
影响因子：
--
作者：
Nobles CJ;Grantz KL;Liu D;Williams A;Ouidir M;Seeni I;Sherman S;Mendola P
通讯作者：
Mendola P
影响因子：
10.4
作者：
Nachman RM;Mao G;Zhang X;Hong X;Chen Z;Soria CS;He H;Wang G;Caruso D;Pearson C;Biswal S;Zuckerman B;Wills-Karp M;Wang X
通讯作者：
Wang X