Subjective Cognitive Decline Is More Accurate When Metamemory Is Better.
Subjective Cognitive Decline Is More Accurate When Metamemory Is Better.
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元记忆越好，主观认知衰退的判断就越准确。
DOI：
10.3389/fnagi.2022.787552
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发表时间：
2022
影响因子：
4.8
通讯作者：
Cosentino S
中科院分区：
文献类型：
--
作者：
Chapman S;Joyce JL;Barker MS;Sunderaraman P;Rizer S;Huey ED;Dworkin J;Gu Y;Cosentino S
主观认知功能下降(SCD)是阿尔茨海默病(AD)的主要表现之一。然而，它与记忆和其他认知能力测试的关系上的差异阻碍了SCD的诊断作用。元记忆或记忆意识的个体间异质性，以及对早期认知功能障碍缺乏敏感性的临床认知测量的使用，可能会导致这些差异。我们的目的是评估SCD和早期认知功能障碍的标记物之间的关系是否受到元记忆能力的调节。样本包括79名认知健康的老年人(77%女性，68%白人，32%黑人参与者)，他们的平均年龄为74.4岁(SD=6.1)，受教育年限为15.9年(SD=2.7)。元记忆是通过四个5项试验的情景知晓测试来评估的。结果衡量标准包括被定义为伽马相关性的分辨率指标，该指标反映了项目级预测的准确性(“你知道正确答案吗？”)。早期认知功能障碍通过Loewenstein-Acevedo语义干扰和学习量表(Lassi-L)和短期记忆结合测试(STMB)进行评估，这两个指标对临床前AD敏感。对SCD进行评估的是一份包含20个项目的问卷，要求参与者在7分的利克特量表上将自己与其他年龄相仿的人进行比较。回归分析检验了SCD和早期认知功能障碍之间的潜在关系是否受到元记忆的调节。主观认知下降与语义主动干扰的易感性有关，因此更多的抱怨仅与语义主动干扰的易感性增加相关(b=−0.30，p=0.003)。元记忆调节了SCD与语义前摄干扰的易感性和恢复之间的关联，使得元记忆更准确的人在抱怨增加和语义前摄干扰易感性之间显示出更强的关联(b=−0.71，p=0.005；b=−0.62，p=0.034)。然而，元记忆并没有缓和SCD与回溯性语义干扰或短期记忆绑定之间的联系。个体元记忆的准确性，特别是他们根据自己的表现调整时刻对时刻预测的能力，可以影响SCD映射到客观认知的程度。在解释SCD时，应该考虑这种自我参照的评估。
Subjective cognitive decline (SCD) has emerged as one of the first manifestations of Alzheimer’s disease (AD). However, discrepancies in its relationship with tests of memory and other cognitive abilities have hindered SCD’s diagnostic utility. Inter-individual heterogeneity in metamemory, or memory awareness, and the use of clinical measures of cognition lacking sensitivity to early cognitive dysfunction, may contribute to these discrepancies. We aimed to assess if the relationship between SCD and markers of early cognitive dysfunction is moderated by metamemory abilities. The sample included 79 cognitively healthy older adults (77% female, 68% White, and 32% Black participants) with a mean age of 74.4 (SD = 6.1) and 15.9 (SD = 2.7) years of education. Metamemory was assessed using an episodic Feeling of Knowing test with four 5-item trials. Outcome measures included a resolution metric defined as a gamma correlation reflecting the accuracy of item-level predictions (“Will you know the correct answer?”). Early cognitive dysfunction was measured through the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L) and the Short-Term Memory Binding Test (STMB), measures sensitive to preclinical AD. SCD was assessed with a 20-item questionnaire that asked participants to compare themselves to others their age on a 7-point Likert scale. Regression analyses examined whether a potential relation between SCD and early cognitive dysfunction was moderated by metamemory. Subjective cognitive decline was associated with susceptibility to semantic proactive interference such that greater complaints were associated with increased susceptibility to semantic proactive interference (b = −0.30, p = 0.003) only. Metamemory moderated the association between SCD and susceptibility to and recovery of semantic proactive interference such that those with more accurate metamemory showed a stronger association between increased complaints and susceptibility to semantic proactive interference (b = −0.71, p = 0.005; b = −0.62, p = 0.034). Metamemory, however, did not moderate the association of SCD with retroactive semantic interference nor short term memory binding. The accuracy of an individual’s metamemory, specifically their ability to adjust moment to moment predictions in line with their performance, can influence the extent to which SCD maps onto objective cognition. Such self-referential assessment should be considered when interpreting SCD.
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影响因子：
2.6
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
通讯作者：
Rentz DM
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3.2
作者：
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作者：
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通讯作者：
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影响因子：
2.6
作者：
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通讯作者：
Abrahams, Sharon
影响因子：
1.8
作者：
Cauvin, Stephanie;Moulin, Christopher J. A.;Schnitzspahn, Katharina M.
通讯作者：
Schnitzspahn, Katharina M.