Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue.
Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue.
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DOI：
10.1038/s41536-023-00286-3
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发表时间：
2023-02-25
影响因子：
7.2
通讯作者：
Guo, Weihua
中科院分区：
文献类型：
--
作者：
Wen, Bo;Dai, Yuguo;Han, Xue;Huo, Fangjun;Xie, Li;Yu, Mei;Wang, Yuru;An, Ning;Li, Zhonghan;Guo, Weihua
颌面部因创伤或感染等原因造成的硬组织缺损常影响颅面功能。以天然硬组织结构为模板，构建组织工程化修复模块是实现颌面部硬组织功能性再生修复的重要方案。在这里，受生物矿化过程的启发，我们构建了一个复合矿物基质水凝胶PAA-CMC-TDM包含无定形磷酸钙（ACP），聚丙烯酸（PAA），羧甲基壳聚糖（CMC）和牙本质基质（TDM）。Ca 2+·COO−配位与ACP形成的动态网络使水凝胶负载TDM，具有自修复能力和可注射性。PAA-CMC-TDM的力学性能可以调节，但TDM的功能活性不受影响。细胞学研究和硬组织缺损动物模型表明，该水凝胶可促进间充质干细胞的成牙或成骨分化，适应不规则硬组织缺损，促进缺损牙和骨组织原位再生。综上所述，本文表明基于仿生矿化理论的可注射TDM水凝胶可以诱导硬组织形成并促进牙本质/骨再生。
Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca2+·COO− coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.
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影响因子：
5.4
作者：
An S;Gao Y;Huang Y;Jiang X;Ma K;Ling J
通讯作者：
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影响因子：
6.2
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Adams, Sarah
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Fawzy El-Sayed KM
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62.1
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14
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Buma, P;Schreurs, W;Verdonschot, N
通讯作者：
Verdonschot, N