Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR.
Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR.
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DOI：
10.1021/acs.nanolett.7b04924
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发表时间：
2018-07-11
期刊：
影响因子：
10.8
通讯作者：
Dvir T
中科院分区：
文献类型：
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作者：
Malki M;Fleischer S;Shapira A;Dvir T
尽管心脏补片有望修复梗死的心脏，但它们通过缝线与心肌结合可能会对患病器官造成进一步的损害。为了解决这个问题，我们开发了简便、安全、无缝线的技术，用于将工程组织附着到器官上。在这里，白蛋白电纺纤维和金纳米棒(AuNRs)组成的纳米复合支架被开发出来。将心肌细胞种植在支架内，并组装成一个功能良好的贴片。然后将工程化组织定位在心肌上，并用近红外激光(808 Nm)照射。AuNRs能够吸收光线并将其转化为热能，这在局部改变了纤维支架的分子结构，并强烈但安全地将其附着在心壁上。这种混合生物材料未来可以用来将任何工程组织与任何有缺陷的器官整合在一起，同时将传统缝合方法对患者造成额外伤害的风险降至最低。
Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. To address this issue, we developed facile and safe, suture-free technology for the attachment of engineered tissues to organs. Here, nanocomposite scaffolds comprised of albumin electrospun fibers and gold nanorods (AuNRs) were developed. Cardiac cells were seeded within the scaffolds and assembled into a functioning patch. The engineered tissue was then positioned on the myocardium and irradiated with a near IR laser (808 nm). The AuNRs were able to absorb the light and convert it to thermal energy, which locally changed the molecular structure of the fibrous scaffold, and strongly, but safely, attached it to the wall of the heart. Such hybrid biomaterials can be used in the future to integrate any engineered tissue with any defected organs, while minimizing the risk of additional injury for the patient, caused by the conventional stitching methods.
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影响因子：
6.2
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1216441109
发表时间：
2012-12-26
影响因子：
11.1
作者：
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通讯作者：
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DOI：
10.1073/pnas.0812242106
发表时间：
2009-09-01
影响因子：
11.1
作者：
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影响因子：
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