Cancer research by means of tissue engineering--is there a rationale?
Cancer research by means of tissue engineering--is there a rationale?
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DOI：
10.1111/jcmm.12130
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发表时间：
2013-10
影响因子：
5.3
通讯作者：
Arkudas A
中科院分区：
文献类型：
--
作者：
Horch RE;Boos AM;Quan Y;Bleiziffer O;Detsch R;Boccaccini AR;Alexiou C;Sun J;Beier JP;Arkudas A
组织工程（TE）通过在实验室中创造功能性替代品，为治疗器官衰竭和组织损失带来了新的希望。除了再生医学（RM）背景下的各种创新外，TE还为研究血管生成和肿瘤细胞生长机制以及癌症研究中潜在的肿瘤细胞扩散提供了新的技术平台。干细胞技术（包括胚胎干细胞和成体干细胞以及诱导多能干细胞）的最新进展清楚地表明，当这些技术将用于患者时，需要更好地了解控制细胞生长的所有相关机制。这种TE-Cancer研究模型使我们能够研究在可变给定条件下复制、形态发生、分化和生长的初始阶段复制生理和病理条件时发生的相互作用。组织微环境在TE的许多领域得到了广泛的研究，它在细胞信号传导和正常和恶性细胞功能的调节中起着至关重要的作用。本文旨在概述TE和RM方法的一些最新发展和可能的应用，以改进TE平台的癌症研究。利用分子生物学和干细胞技术的创新方法合成TE可能有助于研究和潜在地调节肿瘤生长和扩散的主要现象，以及肿瘤相关的血管生成。在未来，这些模型有潜力研究促进肿瘤生长的最佳材料、培养条件和材料结构。
Tissue engineering (TE) has evoked new hopes for the cure of organ failure and tissue loss by creating functional substitutes in the laboratory. Besides various innovations in the context of Regenerative Medicine (RM), TE also provided new technology platforms to study mechanisms of angiogenesis and tumour cell growth as well as potentially tumour cell spreading in cancer research. Recent advances in stem cell technology – including embryonic and adult stem cells and induced pluripotent stem cells – clearly show the need to better understand all relevant mechanisms to control cell growth when such techniques will be administered to patients. Such TE-Cancer research models allow us to investigate the interactions that occur when replicating physiological and pathological conditions during the initial phases of replication, morphogenesis, differentiation and growth under variable given conditions. Tissue microenvironment has been extensively studied in many areas of TE and it plays a crucial role in cell signalling and regulation of normal and malignant cell functions. This article is intended to give an overview on some of the most recent developments and possible applications of TE and RM methods with regard to the improvement of cancer research with TE platforms. The synthesis of TE with innovative methods of molecular biology and stem-cell technology may help investigate and potentially modulate principal phenomena of tumour growth and spreading, as well as tumour-related angiogenesis. In the future, these models have the potential to investigate the optimal materials, culture conditions and material structure to propagate tumour growth.
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影响因子：
3.6
作者：
Hinescu, Mihail E.;Gherghiceanu, Mihaela;Suciu, Laura;Popescu, Laurentiu M.
通讯作者：
Popescu, Laurentiu M.
影响因子：
5.3
作者：
Ceafalan L;Gherghiceanu M;Popescu LM;Simionescu O
通讯作者：
Simionescu O
影响因子：
6.4
作者：
Burdett, Emily;Kasper, F. Kurtis;Ludwig, Joseph A.
通讯作者：
Ludwig, Joseph A.
影响因子：
1.6
作者：
Beier, J. P.;Hess, A.;Kneser, U.
通讯作者：
Kneser, U.
影响因子：
5.3
作者：
Creţoiu SM;Creţoiu D;Popescu LM
通讯作者：
Popescu LM