Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men.
Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men.
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DOI：
10.1177/07487304211013995
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发表时间：
2021-08
影响因子：
3.5
通讯作者：
Reichert CF
中科院分区：
文献类型：
--
作者：
Weibel J;Lin YS;Landolt HP;Berthomier C;Brandewinder M;Kistler J;Rehm S;Rentsch KM;Meyer M;Borgwardt S;Cajochen C;Reichert CF
大量摄入咖啡因会减轻体内平衡睡眠压力，降低睡眠质量。摄入咖啡因--尤其是在高剂量和接近就寝时间时--也可能影响昼夜调节的快速眼动(REM)睡眠促进，这是主观睡眠质量的一个重要决定因素。然而，在白天长期摄入咖啡因的情况下，这种变化是否会持续尚不清楚。20名男性咖啡因消费者(26.4±4岁，咖啡因习惯性摄入量478.1±102.8 mg/d)参与了一项双盲交叉研究。每个志愿者完成了咖啡因(每天3×150毫克咖啡因，持续10天)、停用咖啡因(3×150毫克咖啡因，持续8天，然后是安慰剂)和安慰剂条件。在控制摄入量和固定的睡眠-觉醒周期后，我们记录了8h的脑电，从习惯性睡前5h开始(即平均开始于4点22h，大约是昼夜REM睡眠促进的峰值)。在每一次睡眠之前，晚上小睡60分钟，可以降低高睡眠压力水平。虽然总睡眠时间和睡眠结构在三种情况下没有显著差异，但与安慰剂和停药相比，每天摄入咖啡因后的REM睡眠潜伏期更长。此外，快速眼动睡眠比例的积累被推迟，志愿者报告说，与安慰剂相比，咖啡因状态下的睡眠后觉醒更困难，醒来时感觉更累。我们的数据表明，除了急性摄取，有规律的白天咖啡因摄入也会影响男性的REM睡眠调节，因此与安慰剂相比，它会推迟昼夜REM睡眠的促进。此外，观察到的咖啡因引起的觉醒质量恶化可能表明了在睡眠后恢复咖啡因摄入量的潜在动机。
Acute caffeine intake can attenuate homeostatic sleep pressure and worsen sleep quality. Caffeine intake—particularly in high doses and close to bedtime—may also affect circadian-regulated rapid eye movement (REM) sleep promotion, an important determinant of subjective sleep quality. However, it is not known whether such changes persist under chronic caffeine consumption during daytime. Twenty male caffeine consumers (26.4 ± 4 years old, habitual caffeine intake 478.1 ± 102.8 mg/day) participated in a double-blind crossover study. Each volunteer completed a caffeine (3 × 150 mg caffeine daily for 10 days), a withdrawal (3 × 150 mg caffeine for 8 days then placebo), and a placebo condition. After 10 days of controlled intake and a fixed sleep-wake cycle, we recorded electroencephalography for 8 h starting 5 h after habitual bedtime (i.e., start on average at 04:22 h which is around the peak of circadian REM sleep promotion). A 60-min evening nap preceded each sleep episode and reduced high sleep pressure levels. While total sleep time and sleep architecture did not significantly differ between the three conditions, REM sleep latency was longer after daily caffeine intake compared with both placebo and withdrawal. Moreover, the accumulation of REM sleep proportion was delayed, and volunteers reported more difficulties with awakening after sleep and feeling more tired upon wake-up in the caffeine condition compared with placebo. Our data indicate that besides acute intake, also regular daytime caffeine intake affects REM sleep regulation in men, such that it delays circadian REM sleep promotion when compared with placebo. Moreover, the observed caffeine-induced deterioration in the quality of awakening may suggest a potential motive to reinstate caffeine intake after sleep.
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影响因子：
3.2
作者：
James, JE
通讯作者：
James, JE
DOI：
10.1016/s0169-328x(99)00219-3
发表时间：
1999-11-10
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Basheer, R;Porkka-Heiskanen, T;McCarley, RW
通讯作者：
McCarley, RW
影响因子：
4.7
作者：
della Monica, Ciro;Johnsen, Sigurd;Dijk, Derk-Jan
通讯作者：
Dijk, Derk-Jan
影响因子：
4.2
作者：
Gaggioni, Giulia;Ly, Julien Q. M.;Vandewalle, Gilles
通讯作者：
Vandewalle, Gilles
影响因子：
4.4
作者：
Drapeau, Caroline;Hamel-Hebert, Isabelle;Carrier, Julie
通讯作者：
Carrier, Julie