Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis.
Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis.
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中国阿尔茨海默病和帕金森病的患病率：最新系统分析
DOI：
10.3389/fnagi.2020.603854
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发表时间：
2020
影响因子：
4.8
通讯作者：
Zhu JH
中科院分区：
文献类型：
--
作者：
Cui L;Hou NN;Wu HM;Zuo X;Lian YZ;Zhang CN;Wang ZF;Zhang X;Zhu JH
背景：阿尔茨海默病（AD）和帕金森病（PD）是世界范围内两种主要的神经退行性疾病。我国人口老龄化进程迅速。尚未提供AD和PD患病率的最新估计值。方法：通过系统性数据库检索1985年至2018年，确定了报告中国AD和PD患病率的研究。采用Meta分析、局部多项式回归和自回归移动平均模型进行分析。结果：共纳入99项研究，AD和PD的人群分别为385，312和227，228。在年龄标准化后，60岁以上的个体中AD和PD的总患病率分别为3.20% [95%置信区间（CI）= 3.17-3.23]和1.06%（95% CI = 1.02-1.10）。年龄每增加10岁，发病率急剧增加。AD的年患病率预计在未来5年内将从3.81%上升到6.17%。男性与女性AD的比值比（OR）为0.57，95%CI为0.51-0.64; PD的OR = 1.25，95% CI = 1.06-1.46]，不同教育水平之间（文盲与非文盲AD的OR = 2.99，95%CI = 2.38-3.75），但在城市和农村环境之间没有。结论：我们的研究结果提供了一个最新的洞察AD和PD在中国的流行病学及其相关的比率和比率。研究结果有助于中国的政策制定者和卫生专业人员缓解相关的健康问题。
Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified via a systematic database search from 1985 to 2018. Meta-analysis, local polynomial regression and autoregressive integrated moving average model were used for analyses. Results: A total of 99 studies were included in the study with populations of 385,312 and 227,228, respectively for AD and PD. The overall prevalence of AD and PD following age standardization was 3.20% [95% confidence interval (CI) = 3.17–3.23] and 1.06% (95% CI = 1.02–1.10), respectively in individuals over 60 years old. The rates increased drastically for every 10-years increment of age. The yearly prevalence of AD was predicted to increase from 3.81 to 6.17% in the next 5 years. Significant differences were observed between genders [male to female odds ratio (OR) for AD = 0.57, 95% CI = 0.51–0.64; OR for PD = 1.25, 95% CI = 1.06–1.46], and between education levels (Illiterate to non-illiterate OR for AD = 2.99, 95% CI = 2.38–3.75), but not between urban and rural settings. Conclusion: Our results provide an updated insight into the epidemiology of AD and PD in China and their associated rates and ratios. The findings may facilitate China policy makers and health professionals mitigate the related health issues.
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DOI：
10.1002/mds.27037
发表时间：
2017-07
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Collier TJ;Kanaan NM;Kordower JH
通讯作者：
Kordower JH
影响因子：
48
作者：
Kalaria, Raj N.;Maestre, Gladys E.;Arizaga, Raul;Friedland, Robert P.;Galasko, Doug;Hall, Kathleen;Luchsinger, Jose A.;Ogunniyi, Adesola;Perry, Elaine K.;Potocnik, Felix;Prince, Martin;Stewart, Robert;Wimo, Anders;Zhang, Zhen-Xin;Antuono, Piero
通讯作者：
Antuono, Piero
影响因子：
168.9
作者：
Kalia, Lorraine V.;Lang, Anthony E.
通讯作者：
Lang, Anthony E.
影响因子：
--
作者：
Gao, S;Hendrie, HC;Hall, KS
通讯作者：
Hall, KS
影响因子：
4
作者：
Kim, Ki Woong;Park, Joon Hyuk;Cho, Maeng Je
通讯作者：
Cho, Maeng Je