The role of H2O2 outer diffusion on the performance of implantable glucose sensors.
The role of H2O2 outer diffusion on the performance of implantable glucose sensors.
复制标题
DOI：
10.1016/j.bios.2008.08.015
复制
发表时间：
2009-02-15
影响因子：
12.6
通讯作者：
Papadimitrakopoulos F
中科院分区：
文献类型：
--
作者：
Vaddiraju S;Burgess DJ;Jain FC;Papadimitrakopoulos F
植入式葡萄糖传感器的性能在很大程度上取决于其外膜控制各种参与物质扩散的能力。在该贡献中，使用一系列逐层（LBL）组装的外膜，H2 O2通过葡萄糖传感器的外膜向外扩散的作用与传感器灵敏度相关。具有高渗透性腐殖酸/铁阳离子（HAs/Fe 3+）外膜的葡萄糖传感器与涂覆有低渗透性外膜（即HAs/聚（二烯丙基二甲基氯化铵）（PDDA）和聚（苯乙烯磺酸盐）（PSS）/PDDA）的传感器相比，显示出较低的灵敏度和较好的线性度的组合。通过这些膜的氧依赖性的综合评价的基础上，它这些传感器结合的渗透性的H2 O2的结论是，H2 O2的外扩散是至关重要的，以达到最佳的传感器性能。这一发现对采用选择性渗透膜的各种生物传感元件的设计具有重要意义。
The performance of an implantable glucose sensor is strongly dependent on the ability of their outer membrane to govern the diffusion of the various participating species. In this contribution, using a series of layer by layer (LBL) assembled outer membranes, the role of outwards of H2O2 diffusion through the outer membrane of glucose sensors has been correlated to sensor sensitivity. Glucose sensors with highly permeable Humic Acids/Ferric cations (HAs/Fe3+) outer membranes displayed a combination of lower sensitivities and better linearities when compared with sensors coated with lesser permeable outer membranes (namely HAs/poly (diallyldimethylammonium chloride) (PDDA) and poly (styrene sulfonate) (PSS)/PDDA). On the basis of a comprehensive evaluation of the oxygen dependence of through these membranes, it these sensors in conjunction with the permeability of H2O2 was concluded that the outer diffusion of H2O2 is crucial to attain optimized sensor performance. This finding has important implications to the design of various bio-sensing elements employing perm-selective membranes.
登录
查看更多内容
影响因子：
3.9
作者：
Baronas, R;Ivanauskas, F;Kulys, J
通讯作者：
Kulys, J
影响因子：
8.4
作者：
Cambiaso, A;Delfino, L;Vadgama, P
通讯作者：
Vadgama, P
影响因子：
3.9
作者：
Kirwan, Sarah M.;Rocchitta, Gaia;O'Neill, Robert D.
通讯作者：
O'Neill, Robert D.
影响因子：
3
作者：
Dixon, BM;Lowry, JP;O'Neill, RD
通讯作者：
O'Neill, RD
影响因子：
6.2
作者：
Galeska, I;Hickey, T;Papadimitrakopoulos, F
通讯作者：
Papadimitrakopoulos, F