Bilayer Poly(Lactic-co-glycolic acid)/Nano-Hydroxyapatite Membrane with Barrier Function and Osteogenesis Promotion for Guided Bone Regeneration.
Bilayer Poly(Lactic-co-glycolic acid)/Nano-Hydroxyapatite Membrane with Barrier Function and Osteogenesis Promotion for Guided Bone Regeneration.
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具有屏障功能和促进成骨作用的双层聚乳酸-乙醇酸/纳米羟基磷灰石膜，用于引导骨再生
DOI：
10.3390/ma10030257
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发表时间：
2017-03-03
期刊：
影响因子：
--
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Fu L;Wang Z;Dong S;Cai Y;Ni Y;Zhang T;Wang L;Zhou Y
引导骨再生（GBR）是一种这样的治疗，其通过使用屏障膜来重建新骨组织，以防止软组织的侵入并产生用于引导新骨生长到骨缺损中的空间。在此，我们报告了一种新的功能梯度双层膜（FGBM）的GBR应用。采用相转化法制备致密层，静电纺丝法制备多孔层的聚乳酸-羟基乙酸共聚物/纳米羟基磷灰石复合膜，并对复合膜的表面形貌、力学性能、降解性能、细胞屏障功能和体外成骨活性进行了研究。结果表明，在致密层中加入5% nHA的PLGA，即使在后降解条件下，也能满足力学强度的要求，并具有良好的阻隔功能。多孔层中nHA含量为30%的PLGA可获得较好的物理化学性能。此外，30%nHA掺入可增强体外矿化，并具有上级其他组的细胞粘附、增殖和分化能力。因此，所设计的FGBM可以潜在地用作优先组织向内生长的屏障，并实现骨组织再生的期望的治疗结果。
Guided bone regeneration (GBR) is one such treatment that reconstructs neo-bone tissue by using a barrier membrane to prevent the invasion of soft tissue and to create a space for guiding new bone growth into the bone defect. Herein, we report a novel functionally graded bilayer membrane (FGBM) for GBR application. To fabricate the novel membrane, the composites of poly(lactic-co-glycolic acid) and nano-hydroxyapatite were prepared by phase inversion for the dense layer and by electrospinning for another porous layer, and their corresponding properties were evaluated including surface morphology, mechanics, degradability, cell barrier function, and in vitro osteogenic bioactivity. The results showed that PLGA with 5% nHA in dense layer could meet the requirement of mechanical strength and have excellent barrier function even on condition of post-degradation. Furthermore, PLGA with 30% nHA in porous layer could achieve the good physical and chemical properties. In addition, 30% nHA incorporation would enhance the in vitro mineralization, and have superior capabilities of cell adhesion, proliferation and differentiation compared to other groups. Therefore, the designed FGBM could potentially serve as a barrier for preferential tissue ingrowth and achieve a desirable therapeutic result for bone tissue regeneration.
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