Dual projecting cells linking thalamic and cortical communication routes between the medial prefrontal cortex and hippocampus.
Dual projecting cells linking thalamic and cortical communication routes between the medial prefrontal cortex and hippocampus.
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DOI：
10.1016/j.nlm.2022.107586
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发表时间：
2022-03
影响因子：
2.7
通讯作者：
Allen TA
中科院分区：
文献类型：
--
作者：
Schlecht M;Jayachandran M;Rasch GE;Allen TA
内侧前额叶皮质（mPFC）和海马（HC）之间的相互作用对于记忆和决策至关重要，并且特别涉及几种神经系统疾病，包括精神分裂症，癫痫，额颞叶痴呆和阿尔茨海默病。腹侧中线丘脑（vmThal），和外侧内嗅皮层和嗅周皮层（LEC/PER）构成了促进记忆中mPFC-HC相互作用的主要通信途径。虽然vmThal和LEC/PER电路已经被单独描绘，但我们试图确定这两个区域是否共享可能同时影响两条路线的细胞特异性输入。为此，我们使用了双重荧光逆行追踪方法，使用霍乱毒素亚基B（CTB-488和CTB-594），在大鼠中注射靶向vmThal和LEC/PER。在mPFC-HC系统中的关键感兴趣区域检查了逆行细胞体标记，包括：（1）mPFC，特别是前扣带回皮质（ACC），背侧和腹侧前边缘皮质（2）内侧隔（MS）和外侧隔（LS）;（3）沿着背腹轴和近远轴的下托（Sub）;（4）LEC和内侧内嗅皮质（MEC）。结果显示，在MS、vSub以及LEC和MEC的浅层II/III中发现双vmThal-LEC/PER投射细胞群。我们没有发现任何双重投射细胞在mPFC或在角ammonis（CA）亚领域的HC。因此，mPFC和HC活性通过非重叠投射细胞群发送到vmThal和LEC/PER。重要的是，MS，vSub和EC中的双投射细胞群处于独特的位置，可以同时影响对记忆至关重要的皮质和丘脑mPFC-HC通路。
The interactions between the medial prefrontal cortex (mPFC) and the hippocampus (HC) are critical for memory and decision making and have been specifically implicated in several neurological disorders including schizophrenia, epilepsy, frontotemporal dementia, and Alzheimer’s disease. The ventral midline thalamus (vmThal), and lateral entorhinal cortex and perirhinal cortex (LEC/PER) constitute major communication pathways that facilitate mPFC-HC interactions in memory. Although vmThal and LEC/PER circuits have been delineated separately we sought to determine whether these two regions share cell-specific inputs that could influence both routes simultaneously. To do this we used a dual fluorescent retrograde tracing approach using cholera toxin subunit-B (CTB-488 and CTB-594) with injections targeting vmThal and the LEC/PER in rats. Retrograde cell body labeling was examined in key regions of interest within the mPFC-HC system including: (1) mPFC, specifically anterior cingulate cortex (ACC), dorsal and ventral prelimbic cortex (dPL, vPL), and infralimbic cortex (IL); (2) medial and lateral septum (MS, LS); (3) subiculum (Sub) along the dorsal-ventral and proximal-distal axes; and (4) LEC and medial entorhinal cortex (MEC). Results showed that dual vmThal-LEC/PER-projecting cell populations are found in MS, vSub, and the shallow layers II/III of LEC and MEC. We did not find any dual projecting cells in mPFC or in the cornu ammonis (CA) subfields of the HC. Thus, mPFC and HC activity is sent to vmThal and LEC/PER via non-overlapping projection cell populations. Importantly, the dual projecting cell populations in MS, vSub, and EC are in a unique position to simultaneously influence both cortical and thalamic mPFC-HC pathways critical to memory.
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影响因子：
3.1
作者：
Canto CB;Wouterlood FG;Witter MP
通讯作者：
Witter MP
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5.3
作者：
Cholvin, Thibault;Hok, Vincent;Poucet, Bruno
通讯作者：
Poucet, Bruno
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2.5
作者：
BECKSTEAD, RM
通讯作者：
BECKSTEAD, RM
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Bartko, Susan J.;Winters, Boyer D.;Bussey, Timothy J.
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作者：
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通讯作者：
Barbas H