Diabetes and urothelial cancer risk: the Multiethnic Cohort study.
Diabetes and urothelial cancer risk: the Multiethnic Cohort study.
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DOI：
10.1016/j.canep.2011.02.014
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发表时间：
2011-12
影响因子：
2.6
通讯作者：
Kolonel, Laurence N.
中科院分区：
文献类型：
--
作者：
Woolcott, Christy G.;Maskarinec, Gertraud;Haiman, Christopher A.;Henderson, Brian E.;Kolonel, Laurence N.
了解糖尿病发病率上升可能导致的不良健康后遗症是很重要的。糖尿病患者患尿路上皮癌的风险可能会增加，但来自前瞻性研究和种族多样性人群的证据很少。我们在夏威夷和洛杉矶进行的多种族队列（MEC）中检查了这种关联，其中有五个种族的近186，000名参与者。在中位10.7年的随访中，通过肿瘤登记联系确定了918例尿路上皮癌（89%为膀胱癌，11%为其他泌尿道部位癌）。自我报告的糖尿病诊断与尿路上皮癌风险增加相关（相对风险= 1.25; 95%置信区间：1.04-1.50）。这种关联不能用体重指数、体力活动或吸烟来解释。有一些建议认为，女性，白人和非洲裔美国人以及过去的吸烟者的风险更高。与糖尿病相关的原位和局部癌症的风险与区域和远处癌症的风险相似。这项研究表明，在这个多种族人群中，糖尿病增加的尿路上皮癌风险与大多数白色或亚洲人群中观察到的非常相似。糖尿病相关高血糖症的控制程度是否会降低风险升高，需要在未来的研究中确定。
It is important to understand the adverse health sequelae that may result from the rising incidence of diabetes. Diabetics may have an increased risk for urothelial cancer but the evidence from prospective studies and ethnically diverse populations is sparse. We examined this association in the Multiethnic Cohort (MEC) that was conducted in Hawaii and Los Angeles with nearly 186,000 participants in five ethnic groups. Over a median 10.7 years of follow-up, 918 incident cases of urothelial cancer (89% bladder and 11% other urinary tract sites) were identified through tumor registry linkages. A self-reported diagnosis of diabetes was associated with an increased risk of urothelial cancer (relative risk = 1.25; 95% confidence interval: 1.04–1.50). The association was not explained by body mass index, physical activity, or smoking. There was some suggestion that the risk was higher in women, Whites and African Americans, and past smokers. The risk associated with diabetes for in situ and localized cancer was similar to that for regional and distant cancer. This study demonstrates that the increased urothelial cancer risk with diabetes in this multiethnic population is very similar to that observed in mostly White or Asian populations. Whether or not the elevated risk is moderated by the degree of control of the hyperglycemia associated with diabetes will need to be determined in future studies.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
16.2
作者：
Schulze, Matthias B.;Hoffmann, Kurt;Joost, Hans-Georg
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Joost, Hans-Georg
影响因子：
6.6
作者：
Zhao, H;Grossman, HB;Wu, XF
通讯作者：
Wu, XF
影响因子：
5
作者：
Coughlin, SS;Calle, EE;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
13.6
作者：
Alguacil, Juan;Pfeiffer, Ruth M.;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat