The influence of urban exposures and residence on childhood asthma.
The influence of urban exposures and residence on childhood asthma.
复制标题
城市暴露和居住对儿童哮喘的影响。
DOI：
10.1111/pai.13784
复制
发表时间：
2022-05
影响因子：
4.4
通讯作者：
Wood, Robert A.
中科院分区：
文献类型：
--
作者：
Grant, Torie L.;Wood, Robert A.
关键词：
居住在城市社区的哮喘儿童承受着不成比例的高哮喘负担，哮喘发病率增加，哮喘症状、病情加重、哮喘急性就诊和住院治疗也增加。多种城市暴露因素会导致儿童哮喘发病，包括接触害虫过敏原、霉菌、内毒素以及室内和室外空气污染。生活在城市社区的儿童还经历着健康社会决定因素方面的不平等，例如贫困加剧、住房质量不合格、肥胖率上升以及慢性压力增加。这些差异反过来又会增加城市暴露和复合哮喘发病的风险，因为房屋修缮不良是害虫侵扰和霉菌暴露的风险因素，而贫困是暴露于空气污染的风险因素。降低家庭过敏原浓度的环境干预措施产生了不一致的结果。人口层面的干预措施，包括公共场所禁烟和减少交通相关空气污染的立法，已成功降低哮喘发病率和改善肺功能发育。鉴于城市暴露与健康社会决定因素之间的相互作用和协同作用，可能需要人口和社区层面的变化来减少城市社区儿童的过度哮喘负担。
Children with asthma who live in urban neighborhoods experience a disproportionately high asthma burden, with increased incident asthma as well as increased asthma symptoms, exacerbations, and acute visits and hospitalizations for asthma. There are multiple urban exposures that contribute to pediatric asthma morbidity, including exposure to pest allergens, mold, endotoxin, and indoor and outdoor air pollution. Children living in urban neighborhoods also experience inequities in social determinants of health, such as increased poverty, substandard housing quality, increased rates of obesity, and increased chronic stress. These disparities then in turn can increase the risk of urban exposures and compound asthma morbidity as poor housing repair is a risk factor for pest infestation and mold exposure and poverty is a risk factor for exposure to air pollution. Environmental interventions to reduce in-home allergen concentrations have yielded inconsistent results. Population-level interventions including smoking bans in public places and legislation to decrease traffic-related air pollution have been successful at reducing asthma morbidity and improving lung function growth. Given the interface and synergy between urban exposures and social determinants of health, it is likely population and community-level changes will be needed to decrease the excess asthma burden in children living in urban neighborhoods.
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DOI：
10.1016/j.jaip.2020.01.015
发表时间：
2020-03
期刊：
The journal of allergy and clinical immunology. In practice
影响因子：
--
作者：
Grant T;Brigham EP;McCormack MC
通讯作者：
McCormack MC
影响因子：
14.2
作者：
Grant, Torie;Phipatanakul, Wanda;Matsui, Elizabeth C.
通讯作者：
Matsui, Elizabeth C.
影响因子：
5.8
作者：
Fisk, W. J.;Lei-Gomez, Q.;Mendell, M. J.
通讯作者：
Mendell, M. J.
DOI：
10.1513/pats.200908-083rm
发表时间：
2010-05-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Breysse, Patrick N;Diette, Gregory B;McCormack, Meredith C
通讯作者：
McCormack, Meredith C
影响因子：
168.9
作者：
Guarnieri, Michael;Balmes, John R.
通讯作者：
Balmes, John R.