Association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk: Evidence from epidemiologic studies.
Association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk: Evidence from epidemiologic studies.
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DOI：
10.1038/srep38936
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发表时间：
2016-12-12
影响因子：
4.6
通讯作者：
Zheng J
中科院分区：
文献类型：
--
作者：
Huang X;Gao Y;Zhi X;Ta N;Jiang H;Zheng J
胰腺癌是一种预后不良的毁灭性疾病。维生素A、视黄醇和类胡萝卜素摄入量与胰腺癌发生风险之间的关系仍存在争议，因此有必要进行荟萃分析来阐明维生素A、视黄醇和类胡萝卜素摄入量与胰腺癌风险之间的关系。在本研究中，PubMed 和 EMBASE 数据库用于识别合格的研究。膳食维生素 A、视黄醇和类胡萝卜素之间的关联通过汇总优势比 (OR) 和相应的 95% 置信区间 (CI) 进行评估。结果发现，维生素 A、β-胡萝卜素和番茄红素的摄入量与胰腺癌风险之间存在负相关（对于维生素 A，汇总 OR = 0.85，95%CI = 0.74–0.97，P = 0.015；对于 β-胡萝卜素，汇总 OR = 0.78， 95%CI = 0.66–0.92，P = 0.003； 番茄红素，合并 OR = 0.84，95%CI = 0.73–0.97，P = 0.020），这在病例对照研究亚组中更为突出。总之，膳食维生素 A、β-胡萝卜素和番茄红素可能与胰腺癌呈负相关。
Pancreatic cancer is a devastating disease with poor prognosis. The association between vitamin A, retinol and carotenoid intake and the risk of pancreatic cancer occurrence remains controversial, and therefore it is necessary to make a meta-analysis to clarify the association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk. In the present study, PubMed and EMBASE databases were used to identify qualified studies. The association between dietary vitamin A, retinol and carotenoids was estimated by pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs). It was found that there was an inverse correlation between vitamin A, beta-carotene and lycopene intake and the risk of pancreatic cancer (for vitamin A, pooled OR = 0.85, 95%CI = 0.74–0.97, P = 0.015; for beta-carotene, pooled OR = 0.78, 95%CI = 0.66–0.92, P = 0.003; for lycopene, pooled OR = 0.84, 95%CI = 0.73–0.97, P = 0.020), which was more prominent in case-control study subgroup. In conclusion, dietary vitamin A, beta-carotene and lycopene might inversely correlate with pancreatic cancer.
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DOI：
10.1016/j.bbalip.2011.06.002
发表时间：
2012-01
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Harrison EH
通讯作者：
Harrison EH
影响因子：
4.6
作者：
Fan, Hua;Kou, Jiantao;He, Qiang
通讯作者：
He, Qiang
影响因子：
6.4
作者：
Jeurnink, Suzanne M.;Ros, Martine M.;Bueno-de-Mesquita, H. B(as)
通讯作者：
Bueno-de-Mesquita, H. B(as)
影响因子：
3.5
作者：
Das BC;Thapa P;Karki R;Das S;Mahapatra S;Liu TC;Torregroza I;Wallace DP;Kambhampati S;Van Veldhuizen P;Verma A;Ray SK;Evans T
通讯作者：
Evans T
影响因子：
6.4
作者：
GHADIRIAN, P;SIMARD, A;BOYLE, P
通讯作者：
BOYLE, P