Identification of gene expression changes associated with long-term memory of courtship rejection in Drosophila males.
Identification of gene expression changes associated with long-term memory of courtship rejection in Drosophila males.
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DOI：
10.1534/g3.112.004119
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Arbeitman MN
中科院分区：
文献类型：
--
作者：
Winbush A;Reed D;Chang PL;Nuzhdin SV;Lyons LC;Arbeitman MN
Long-term memory formation in Drosophila melanogaster is an important neuronal function shaping the insect’s behavioral repertoire by allowing an individual to modify behaviors on the basis of previous experiences. In conditioned courtship or courtship suppression, male flies that have been repeatedly rejected by mated females during courtship advances are less likely than naïve males to subsequently court another mated female. This long-term courtship suppression can last for several days after the initial rejection period. Although genes with known functions in many associative learning paradigms, including those that function in cyclic AMP signaling and RNA translocation, have been identified as playing critical roles in long-term conditioned courtship, it is clear that additional mechanisms also contribute. We have used RNA sequencing to identify differentially expressed genes and transcript isoforms between naïve males and males subjected to courtship-conditioning regimens that are sufficient for inducing long-term courtship suppression. Transcriptome analyses 24 hours after the training regimens revealed differentially expressed genes and transcript isoforms with predicted and known functions in nervous system development, chromatin biology, translation, cytoskeletal dynamics, and transcriptional regulation. A much larger number of differentially expressed transcript isoforms were identified, including genes previously implicated in associative memory and neuronal development, including fruitless, that may play functional roles in learning during courtship conditioning. Our results shed light on the complexity of the genetics that underlies this behavioral plasticity and reveal several new potential areas of inquiry for future studies.
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影响因子：
4.4
作者：
Ellis LL;Carney GE
通讯作者：
Carney GE
DOI：
10.1073/pnas.84.22.8026
发表时间：
1987-11-01
影响因子：
11.1
作者：
BELOTE, JM;BAKER, BS
通讯作者：
BAKER, BS
DOI：
10.1523/jneurosci.3190-10.2011
发表时间：
2011-04-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Akalal DB;Yu D;Davis RL
通讯作者：
Davis RL
影响因子：
56.9
作者：
CAREW, TJ;PINSKER, HM;KANDEL, ER
通讯作者：
KANDEL, ER
DOI：
10.1152/physiol.00026.2010
发表时间：
2010-12
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Busto GU;Cervantes-Sandoval I;Davis RL
通讯作者：
Davis RL