Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival.
Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival.
复制标题
血红蛋白 A1c 水平与肌萎缩侧索硬化症生存率
DOI：
10.1186/s13024-017-0211-y
复制
发表时间：
2017-09-21
影响因子：
15.1
通讯作者：
Shang H
中科院分区：
文献类型：
--
作者：
Wei QQ;Chen Y;Cao B;Ou RW;Zhang L;Hou Y;Gao X;Shang H
糖尿病或空腹血糖浓度与肌萎缩侧索硬化症（ALS）发病风险和生存率的相关性在以往的研究中存在不一致。此外，没有研究反映长期血糖状态的血红蛋白A1 c（HbA 1c）水平与ALS生存率之间的关系。一项前瞻性队列研究，包括450例中国散发性ALS患者（254例男性和196例女性;平均年龄：55.4岁）。在平均1.6年的随访中，我们确定了223例死亡。我们分别通过离子交换高效液相色谱法和己糖激酶/葡萄糖-6-磷酸脱氢酶法评估空腹HbA 1c（初次暴露）和葡萄糖（二次暴露）水平。使用多变量考克斯比例风险回归模型计算暴露期间ALS死亡率的风险比（HR）和95%置信区间（CI）。我们的研究结果表明，较高水平的HbA 1c，而不是空腹血糖浓度，与较高的死亡风险显著相关。调整后的HR为1.40（95%置信区间（95% CI）：1.02-1.99），HbA 1c为5.7- 6.4%，2.06（95%置信区间：1.07-3.96），HbA 1c ≥ 6.5%，相对于HbA 1c <5.7%（P趋势=0.01），校正年龄、吸烟、肥胖、疾病严重程度、发病部位、生活方式和其他潜在混杂因素后。空腹血糖浓度≥7.0 mmol/L vs <5.6 mmol/L的校正HR为1.38（95% CI：0.81-2.35，P趋势=0.13）。我们没有观察到HbA 1c水平与年龄、性别、吸烟、体重指数、ALS疾病进展率和发病部位之间有任何显著的相互作用（所有P-相互作用>0.05）。在这项前瞻性研究中，我们观察到基线时HbA 1c水平较高的个体死亡风险较高，这与其他已知的风险因素无关。
There are inconsistences regarding the correlation between diabetes or fasting blood glucose concentrations and the risk and survival of amyotrophic lateral sclerosis (ALS) in the previous studies. Moreover, the association between hemoglobin A1c (HbA1c) levels, which reflect long-term glycemic status, and ALS survival was not examined. A prospective cohort study including 450 Chinese sporadic ALS patients (254 men and 196 women; mean age: 55.4 y). We identified 223 deaths during average 1.6 years of follow-up. We assessed levels of fasting HbA1c (primary exposure) and glucose (secondary exposure) via ion exchange high-performance liquid chromatography and hexokinase/glucose-6-pgosphate dehydrogenase methods, respectively. Multivariate Cox proportional hazards regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of ALS mortality across the exposures. Our results indicated that, higher levels of HbA1c, but not fasting blood glucose concentrations, were significantly associated with higher risks of mortality. The adjusted HR was 1.40 (95% confidence interval (95% CI): 1.02–1.99) for HbA1c of 5.7–6.4%, and 2.06 (95% CI: 1.07–3.96) for HbA1c ≥6.5%, relative to HbA1c <5.7% (P trend =0.01), after adjustment for age, smoking, obesity, disease severity, site of onset, lifestyle, and other potential confounders. The adjusted HR was 1.38 (95% CI: 0.81–2.35, P trend =0.13) for fasting glucose concentrations ≥7.0 mmol/L vs <5.6 mmol/L. We did not observe any significant interactions between HbA1c levels and age, sex, smoking, body mass index, rate of disease progression of ALS, and site of onset (P-interactions >0.05 for all). In this prospective study, we observed that individuals with higher HbA1c levels at the baseline had higher risk of mortality, which is independent of other known risk factors.
登录
查看更多内容
DOI：
10.3109/21678421.2012.735240
发表时间：
2013-04
影响因子：
2.8
作者：
O'Reilly ÉJ;Wang H;Weisskopf MG;Fitzgerald KC;Falcone G;McCullough ML;Thun M;Park Y;Kolonel LN;Ascherio A
通讯作者：
Ascherio A
DOI：
10.3109/00365513.2010.547947
发表时间：
2011-04-01
影响因子：
2.1
作者：
Borai, Anwar;Livingstone, Callum;Ferns, Gordon
通讯作者：
Ferns, Gordon
影响因子：
1.8
作者：
Lekoubou A;Matsha TE;Sobngwi E;Kengne AP
通讯作者：
Kengne AP
DOI：
10.3109/17482960802566824
发表时间：
2009-10
期刊：
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
影响因子：
--
作者：
Chiò A;Logroscino G;Hardiman O;Swingler R;Mitchell D;Beghi E;Traynor BG;Eurals Consortium
通讯作者：
Eurals Consortium
影响因子：
5.1
作者：
Jawaid, A.;Salamone, A. R.;Schulz, P. E.
通讯作者：
Schulz, P. E.