Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials.
Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials.
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评估菊粉型果聚糖摄入量对体重、血糖和血脂的影响：随机对照试验的系统评价和荟萃分析
DOI：
10.1002/fsn3.2403
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发表时间：
2021-08
影响因子：
3.9
通讯作者：
Xu L
中科院分区：
文献类型：
--
作者：
Li L;Li P;Xu L
菊糖型果聚糖（ITF）的摄入被认为可以缓解代谢综合征的几个特征，包括肥胖，糖尿病和高脂血症;然而，人体试验的结果仍然不一致。我们的目的是系统地评估ITF摄入对不同健康状况的人类受试者（包括健康、超重和肥胖、前驱糖尿病和糖尿病以及高脂血症）的体重、葡萄糖稳态和血脂谱的影响。通过随机效应模型计算ITF和对照组之间的加权平均差异（WMD）。共纳入33项随机对照人体试验。仅在糖尿病患者中观察到ITF摄入的显著影响，而在其他受试者组中未观察到。具体而言，ITF干预显著降低了血糖的WMD（−0.42 mmol/L; 95% CI：−0.71，−0.14; p = .004），总胆固醇（−0.46 mmol/L; 95% CI：−0.75，−0.17; p = .002）和甘油三酯（TAG）（−0.21 mmol/L; 95% CI：−0.37，−0.05; p = .01）与对照组相比。通过敏感性分析证实了ITF对糖尿病患者的这些有利作用的稳定性。此外，ITF倾向于降低LDL胆固醇（p = 0.084）。但体重和血胰岛素不受ITF摄入量的影响。应该注意的是，血糖、总胆固醇和LDL胆固醇表现出高度不明原因的异质性。总之，ITF摄入量降低了糖尿病患者的血糖，总胆固醇和TAG，他们可能会从饮食中添加菊粉中受益，但这些影响的潜在机制尚不确定。仅在糖尿病患者中观察到菊糖型果聚糖摄入的显著影响，但在其他受试者组中未观察到，包括健康，超重和肥胖以及高脂血症。
Inulin‐type fructan (ITF) intake has been suggested to alleviate several features of metabolic syndrome including obesity, diabetes, and hyperlipidemia; yet, results from the human trials remained inconsistent. We aimed to systematically evaluate the effects of ITF intake on body weight, glucose homeostasis, and lipid profile on human subjects with different health status, including healthy, overweight and obese, prediabetes and diabetes, and hyperlipidemia. Weighted mean differences (WMDs) between ITF and control groups were calculated by a random‐effects model. A total of 33 randomized controlled human trials were included. Significant effect of ITF intake was only observed in the diabetics, but not in the other subject groups. Specifically, ITF intervention significantly decreased the WMD of blood glucose (−0.42 mmol/L; 95% CI: −0.71, −0.14; p = .004), total cholesterol (−0.46 mmol/L; 95% CI: −0.75, −0.17; p = .002), and triglycerides (TAG) (−0.21 mmol/L; 95% CI: −0.37, −0.05; p = .01) compared with the control. The stability of these favorable effects of ITF on diabetics was confirmed by sensitivity analysis. Also, ITF tends to lower LDL cholesterol (p = .084). But body weight and blood insulin were not affected by ITF intake. It should be noted that blood glucose, total cholesterol, and LDL cholesterol exhibited high unexplained heterogeneity. In conclusion, ITF intake lowers blood glucose, total cholesterol, and TAG in the people with diabetes, and they may benefit from addition of inulin into their diets, but the underlying mechanisms responsible for these effects are inconclusive. Significant effect of inulin‐type fructans intake was only observed in the diabetics, but not in the other subject groups, inculding including healthy, overweight and obese, and hyperlipidemia.
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影响因子：
6.9
作者：
Daud, Norlida M.;Ismail, Nurhafzan A.;Frost, Gary S.
通讯作者：
Frost, Gary S.
影响因子：
4.2
作者：
Daubioul, CA;Taper, HS;Delzenne, NM
通讯作者：
Delzenne, NM
影响因子：
6.3
作者：
Beserra, Bruna T. S.;Fernandes, Ricardo;Trindade, Erasmo B. S. M.
通讯作者：
Trindade, Erasmo B. S. M.
影响因子：
7.1
作者：
Delzenne, NM;Kok, N
通讯作者：
Kok, N
影响因子：
4.2
作者：
Daubioul, C;Rousseau, N;Delzenne, N
通讯作者：
Delzenne, N