Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children.
Predictors of urinary bisphenol A and phthalate metabolite concentrations in Mexican children.
复制标题
DOI：
10.1016/j.chemosphere.2013.08.038
复制
发表时间：
2013-11
期刊：
影响因子：
8.8
通讯作者：
Téllez-Rojo MM
中科院分区：
文献类型：
--
作者：
Lewis RC;Meeker JD;Peterson KE;Lee JM;Pace GG;Cantoral A;Téllez-Rojo MM
接触双酚A(BPA)和邻苯二甲酸盐等内分泌干扰物在儿童和青少年中很普遍，但对这些敏感生命阶段的重要接触来源知之甚少。在这项研究中，我们测量了108名8-13岁墨西哥儿童的尿双酚A和9种邻苯二甲酸酯代谢物的浓度。评估了年龄、一天中的时间以及关于外部环境、水使用和食物容器使用的问卷项目与特定重力校正的尿液浓度的关系，以及关于过去48小时内使用17种个人护理产品的问卷项目。作为次要目标，对99名这些孩子的母亲进行了妊娠晚期尿药浓度的测量，并探讨了这两个时间点的比重校正尿药浓度之间的关系。在调整了过去48小时内其他个人护理产品使用的潜在混杂因素后，有统计学意义(p<；男童使用古龙水/香水与邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单乙酯(MCPP)、邻苯二甲酸单(2-乙基-5-羟基己基)(MEHHP)和邻苯二甲酸单(2-乙基-5-氧己基)(MEOHP)呈正相关，女童使用彩色化妆品和邻苯二甲酸单丁酯(MBP)、邻苯二甲酸单(2-乙基己基)邻苯二甲酸单乙酯(MEHP)、MEHHP、MEOHP和邻苯二甲酸单(2-乙基-5-羧基戊基)酯(MECPP)、使用除臭剂和MEP以及其他头发产品和MBP呈正相关。在过去的48小时内，在女孩中使用的个人护理产品的数量和LOG-MEP的数量在统计上有显著的积极趋势。然而，分析物与其他问卷项目之间没有统计学意义的相关性，在妊娠晚期和8-13岁时测量的分析物之间也没有很强的相关性。我们证明，个人护理产品的使用与儿童暴露于多种邻苯二甲酸盐有关。由于发育迅速，儿童可能容易受到内分泌干扰性化学品的影响；因此，儿童可能有理由减少或推迟使用某些个人护理产品。
Exposure to endocrine disrupting chemicals such as bisphenol A (BPA) and phthalates is prevalent among children and adolescents, but little is known regarding important sources of exposure at these sensitive life stages. In this study, we measured urinary concentrations of BPA and nine phthalate metabolites in 108 Mexican children aged 8–13 years. Associations of age, time of day, and questionnaire items on external environment, water use, and food container use with specific gravity-corrected urinary concentrations were assessed, as were questionnaire items concerning the use of 17 personal care products in the past 48-hr. As a secondary aim, third trimester urinary concentrations were measured in 99 mothers of these children, and the relationship between specific gravity-corrected urinary concentrations at these two time points was explored. After adjusting for potential confounding by other personal care product use in the past 48-hr, there were statistically significant (p <0.05) positive associations in boys for cologne/perfume use and monoethyl phthalate (MEP), mono(3-carboxypropyl) phthalate (MCPP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and in girls for colored cosmetics use and mono-n-butyl phthalate (MBP), mono(2-ethylhexyl) phthalate (MEHP), MEHHP, MEOHP, and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), conditioner use and MEP, deodorant use and MEP, and other hair products use and MBP. There was a statistically significant positive trend for the number of personal care products used in the past 48-hr and log-MEP in girls. However, there were no statistically significant associations between the analytes and the other questionnaire items and there were no strong correlations between the analytes measured during the third trimester and at 8–13 years of age. We demonstrated that personal care product use is associated with exposure to multiple phthalates in children. Due to rapid development, children may be susceptible to impacts from exposure to endocrine disrupting chemicals; thus, reduced or delayed use of certain personal care products among children may be warranted.
登录
查看更多内容
影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
新生儿重症监护室早产儿接触双酚A和其他酚类物质。
影响因子：
10.4
作者：
Calafat, Antonia M.;Weuve, Jennifer;Ye, Xiaoyun;Jia, Lily T.;Hu, Howard;Ringer, Steven;Huttner, Ken;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
--
作者：
Frederiksen, H.;Sorensen, K.;Juul, A.
通讯作者：
Juul, A.
影响因子：
10.4
作者：
Chevrier, Jonathan;Gunier, Robert B.;Harley, Kim G.
通讯作者：
Harley, Kim G.
关于出生结果和脂肪因子表达的母体和脐带血液中双酚A浓度的生物监测：台湾的一项出生队列研究。
DOI：
10.1186/1476-069x-10-94
发表时间：
2011-11-03
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Chou WC;Chen JL;Lin CF;Chen YC;Shih FC;Chuang CY
通讯作者：
Chuang CY