Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol.
Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol.
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DOI：
10.1039/d2bm01335e
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发表时间：
2022-12-06
影响因子：
6.6
通讯作者：
Claeyssens, Frederik
中科院分区：
文献类型：
--
作者：
Aleemardani, Mina;Trikic, Michael Zivojin;Green, Nicola Helen;Claeyssens, Frederik
聚甘油癸二酸酯（PGS）是一种合成生物橡胶，其特点是具有生物相容性、高弹性和可调的机械性能；然而，其固有的疏水性和不溶于水使其不适合用于先进的生物材料，如水凝胶的制造。在这里，我们开发了新的亲水性pgs基共聚物，通过使用两种不同类型的聚乙二醇（PEG），聚乙二醇（PEG2）或甘油乙氧基酸酯（PEG3），以不同的比例组合，可以形成水凝胶。采用两步缩聚反应制得聚癸二酸甘油-聚乙二醇共聚物（PGS-co-PEG），然后在不使用引发剂或交联剂的情况下进行热交联，得到PGS-co-PEG2和PGS-co-PEG3两亲性聚合物。结果表明，PGS-co-PEG共聚物的性能可以通过改变PEG的种类和用量来控制。PEG≥40%的PGS-co-PEG共聚物具有较高的溶胀性、柔韧性、拉伸性、生物粘附性和生物相容性，具有良好的酶降解性能和力学性能。此外，PEG的加入创造了具有ph响应行为的水凝胶，可用于需要响应物理化学动力学的生物应用。有趣的是，PGS-co-40PEG2和PGS-co-60PEG3具有最高的剪切强度，分别为340.4±49.7 kPa和336.0±35.1 kPa，这些都在市售密封胶或生物胶的范围内。由于这些新型共聚物水凝胶具有多种功能，在软组织工程和生物医学方面具有很大的潜力。新型PGS-co-PEG弹性体具有高溶胀性、柔韧性、生物黏附性和生物相容性等多功能特性，具有良好的生物降解、力学性能和ph响应行为。
Poly(glycerol sebacate) (PGS), a synthetic biorubber, is characterised by its biocompatibility, high elasticity and tunable mechanical properties; however, its inherent hydrophobicity and insolubility in water make it unsuitable for use in advanced biomaterials like hydrogels fabrication. Here, we developed new hydrophilic PGS-based copolymers that enable hydrogel formation through use of two different types of polyethylene glycol (PEG), polyethylene glycol (PEG2) or glycerol ethoxylate (PEG3), combined at different ratios. A two-step polycondensation reaction was used to produce poly(glycerol sebacate)-co-polyethylene glycol (PGS-co-PEG) copolymers that were then crosslinked thermally without the use of initiators or crosslinkers, resulting in PGS-co-PEG2 and PGS-co-PEG3 amphiphilic polymers. It has been illustrated that the properties of PGS-co-PEG copolymers can be controlled by altering the type and amount of PEG. PGS-co-PEG copolymers containing PEG ≥ 40% showed high swelling, flexibility, stretching, bioadhesion and biocompatibility, and good enzymatic degradation and mechanical properties. Also, the addition of PEG created hydrogels that demonstrated pH-responsive behaviours, which can be used for bioapplications requiring responding to physicochemical dynamics. Interestingly, PGS-co-40PEG2 and PGS-co-60PEG3 had the highest shear strengths, 340.4 ± 49.7 kPa and 336.0 ± 35.1 kPa, and these are within the range of commercially available sealants or bioglues. Due to the versatile multifunctionalities of these new copolymer hydrogels, they can have great potential in soft tissue engineering and biomedicine. Novel PGS-co-PEG elastomers showed multifunctional characteristics such as high swelling, flexibility, bioadhesiveness and biocompatibility, and good biodegradation, mechanical properties and pH-responsive behaviour.
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影响因子：
6.6
作者：
Khalil IA;Saleh B;Ibrahim DM;Jumelle C;Yung A;Dana R;Annabi N
通讯作者：
Annabi N
影响因子：
18.9
作者：
Hidzir NM;Hill DJT;Martin D;Grøndahl L
通讯作者：
Grøndahl L
影响因子：
6.6
作者：
Aydin, H. M.;Salimi, K.;Piskin, E.
通讯作者：
Piskin, E.
DOI：
10.3390/bioengineering8110148
发表时间：
2021-10-20
期刊：
Bioengineering (Basel, Switzerland)
影响因子：
--
作者：
Aleemardani M;Trikić MZ;Green NH;Claeyssens F
通讯作者：
Claeyssens F
影响因子：
3.4
作者：
Aleemardani, Mina;Solouk, Atefeh;Moeini, Mohammad
通讯作者：
Moeini, Mohammad